The National Institute on Aging (NIA) awarded a $4,276,054 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Regents of the University of California, San Francisco (UCSF) on September 1, 2024. The project aims to develop mathematical models to quantitatively test and validate hypotheses regarding the selective vulnerability of genes, cells, and neural networks in mouse models of Alzheimer's disease (AD) tauopathy. The research will leverage two enabling...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $437,250 to the University of California, San Diego (UCSD) to develop new tools for imaging the tau protein and its phase transitions in living cells. The research aims to map and measure tau in its soluble, liquid-liquid phase separation, and liquid-solid phase separation forms, which is a critical limitation in the field. The project will leverage a peptide-based probe and...
This Project Grant award of $816,661 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a comprehensive research project entitled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics". The research, conducted by The Regents of the University of California, San Francisco, aims to systematically elucidate the molecular and cellular mechanisms by which pathological tau drives neurodegeneration in Alzheimer's disease...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,929,011 to The Regents of the University of California, San Francisco (UCSF) to conduct a longitudinal, multimodal neuroimaging study investigating the role of neuronal dysfunction and hyperexcitability in the early biological progression of Alzheimer's disease. The study aims to elucidate the earliest manifestations of neural circuit hyperexcitability that predict the accumulation of tau...
This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,592,854 to the University of Illinois to conduct research on tau protein conformation and its role in Alzheimer's disease and related dementias. The key focus areas include: Defining the effects of tau post-translational modifications on tau function and pathology. This will evaluate how modifications like phosphorylation, acetylation, and cross-linking impact the exposure of tau's regulatory...
This Project Grant award of $1,526,066 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms by which the protein tau and mitochondrial dysfunction contribute to a broad spectrum of neurodegenerative diseases, including Alzheimer's disease (AD) and related dementias (AD/ADRD). The goal is to use in vivo animal models and human cell culture models to examine how tau regulation of mitochondrial reverse electron transfer (RET) is...
This Project Grant award of $372,690 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to discover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project will develop new statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different AD subpopulations. The goal is to reveal optimal treatment windows and target groups for therapies that reduce amyloid-beta or...
The National Institute on Aging (NIA) awarded a $1,147,300 Project Grant (CFDA 93.866 - Aging Research) to Wayne State University for a project titled "Local Protein Synthesis in Tau Pathology Neurodegeneration". The award period runs from Sep 1, 2024 to Jun 30, 2029. The project aims to investigate how pathogenic forms of the tau protein interfere with dendritic protein synthesis, which may contribute to the synaptic dysfunction observed in Alzheimer's disease. The researchers will...