This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,592,854 to the University of Illinois to conduct research on tau protein conformation and its role in Alzheimer's disease and related dementias. The key focus areas include: Defining the effects of tau post-translational modifications on tau function and pathology. This will evaluate how modifications like phosphorylation, acetylation, and cross-linking impact the exposure of tau's regulatory...
This Project Grant award, with a total funding amount of $130,302.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award, with an effective date of July 15, 2025 and an ultimate completion date of March 31, 2030, supports research at New York University (NYU) to investigate the molecular and functional impacts of pathological tau accumulation in basal forebrain cholinergic neurons and its consequences for Alzheimer's...
This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $921,822 to Yale University to elucidate the molecular mechanisms by which the protein kinase TBK1 helps match lysosome function to cellular demand in neurodegenerative diseases. The research aims to define a new pathway in which TBK1 signals at the lysosome surface, including how the C9ORF72 protein regulates this lysosomal pool of TBK1 and other activators of TBK1 at lysosomes such as...
This $1,823,353 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to the Seattle Institute For Biomedical And Clinical Research aims to elucidate the molecular mechanisms by which pathological tau protein causes neurodegeneration in Alzheimer's disease (AD) and related tauopathy disorders. The research project will leverage a C. elegans model of tauopathy to investigate the functional role of nuclear speckles, membraneless organelles involved in RNA...
The University of Rochester received a $423,500 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) to investigate the role of mitochondrial dysfunction and oxidative stress in the progression of tau pathology in Alzheimer's disease. The two-year project will utilize novel optogenetic tools to spatiotemporally control mitochondrial function and reactive oxygen species production in both ex vivo brain slice cultures and an in vivo mouse model of tau...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $717,709 to Weill Medical College of Cornell University to conduct research on the mechanisms underlying the propagation of tau aggregates in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research aims to discover AD-relevant cellular machinery involved in the spread of misfolded tau proteins using advanced proteomic and transcriptomic techniques. The work will be carried out...
This Project Grant award of $1,526,066 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms by which the protein tau and mitochondrial dysfunction contribute to a broad spectrum of neurodegenerative diseases, including Alzheimer's disease (AD) and related dementias (AD/ADRD). The goal is to use in vivo animal models and human cell culture models to examine how tau regulation of mitochondrial reverse electron transfer (RET) is...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is supporting research at Yale University to investigate the role of the protein CSPα in regulating synaptic autophagy and neurodegeneration. The $461,313 award, active from June 1, 2025 to May 31, 2027, aims to elucidate the mechanisms by which CSPα maintains synaptic vesicle composition and how its deletion or mutations lead to synaptic vesicle turnover through autophagy. The...
This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $3,018,210 to Baylor College of Medicine under the Aging Research program (CFDA 93.866). The grant funds research to functionally dissect a promising transcriptional regulatory network linked to glutamate excitatory signaling that is downregulated in Alzheimer's disease and enriched for suppressors of neurodegeneration. Researchers will perform genetic manipulations in...