This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $461,313 provides funding to Yale University to investigate the role of the protein CSPalpha in regulating synaptic autophagy and neurodegeneration. The award period runs from June 1, 2025 to May 31, 2027. The key objectives are to characterize synaptic vesicles, synaptic vesicles targeted for autophagy, and synaptic autophagosomes in wildtype and CSPalpha knockout models using mass spectrometry and electron microscopy. The researchers will also investigate the relationship between the synaptic vesicle cycle and autophagosome biogenesis by tagging synaptic vesicle proteins with an autophagy reporter in wildtype, CSPalpha knockout, and Cln4 (neurodegeneration) cell culture models. This research aims to advance the understanding of presynaptic autophagy, synaptic vesicle turnover, and their links to neurodegenerative diseases like Cln4 and age-related dementias.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $461.3k | 5/16/25 |