Project Grant K01AG092910

Award Date 7/15/25
Completion Date 3/31/30
Dollars Obligated $130K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New York, NY 10016, USA
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The National Institute on Aging (NIA) awarded a $1,147,300 Project Grant (CFDA 93.866 - Aging Research) to Wayne State University for a project titled "Local Protein Synthesis in Tau Pathology Neurodegeneration". The award period runs from Sep 1, 2024 to Jun 30, 2029. The project aims to investigate how pathogenic forms of the tau protein interfere with dendritic protein synthesis, which may contribute to the synaptic dysfunction observed in Alzheimer's disease. The researchers will...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $717,709 to Weill Medical College of Cornell University to conduct research on the mechanisms underlying the propagation of tau aggregates in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research aims to discover AD-relevant cellular machinery involved in the spread of misfolded tau proteins using advanced proteomic and transcriptomic techniques. The work will be carried out...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,592,854 to the University of Illinois to conduct research on tau protein conformation and its role in Alzheimer's disease and related dementias. The key focus areas include: Defining the effects of tau post-translational modifications on tau function and pathology. This will evaluate how modifications like phosphorylation, acetylation, and cross-linking impact the exposure of tau's regulatory...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
This Project Grant award, with a total funding amount of $431,750, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award is for the development and evaluation of a novel immuno-gene therapy approach using a single-chain fragment variable (scFv) derived from an anti-tau oligomeric complex 1 (TOC1) antibody. The key objectives are to: 1) generate and validate the TOC1-scFv-HaloTag-Proteasome Degradation Signal (PDS)...
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This Project Grant award, with a total funding amount of $130,302.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award, with an effective date of July 15, 2025 and an ultimate completion date of March 31, 2030, supports research at New York University (NYU) to investigate the molecular and functional impacts of pathological tau accumulation in basal forebrain cholinergic neurons and its consequences for Alzheimer's disease progression. The research aims to elucidate the interplay between tau pathology and cholinergic dysfunction, leveraging human induced pluripotent stem cell models and a novel mouse model with restricted tau expression in basal forebrain cholinergic neurons. The findings are expected to provide insights into tau pathogenesis in cholinergic dysfunction and degeneration, and inform potential therapeutics to improve the resilience of these neurons in treating Alzheimer's disease and related tauopathies.

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