Project Grant RF1AG095175
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $417,545 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for a two-year project period (June 1, 2026 – May 31, 2028). The award funds a pooled analysis examining the long-term legacy effects of caloric restriction (CR) and exercise (EX) interventions on bone strength in older adults with obesity. The research leverages existing data from five National Institutes...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Wisconsin-Madison a $1,198,259 Project Grant effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports biomedical research investigating the physiological and molecular mechanisms underlying calorie restriction (CR), prolonged fasting, and mTORC1 protein kinase function in aging and age-related diseases. The research employs multiple...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $599,623 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with a completion date of January 31, 2031. This five-year research initiative investigates the synergistic effects of unacylated ghrelin (UnAG) and endurance exercise (EE) as an intervention strategy to combat sarcopenia and mobility loss in aging populations. The research builds on preliminary...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $6.42 million Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded September 15, 2025, with completion scheduled for September 14, 2029. This award supports a longitudinal research initiative examining how Mediterranean versus Western diet composition moderates cognitive aging trajectories and neuropathology in middle-aged male and female cynomolgus monkeys. The...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $668,290 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 15, 2026, with a completion date of January 31, 2031. The grant funds a five-year research initiative to investigate the metabolism and protective role of docosahexaenoic acid (DHA), an omega-3 essential nutrient implicated in disease prevention but deficient in approximately 80% of the U.S. population....
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $1.54 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded July 1, 2025, with completion scheduled for March 31, 2030. The award supports research on neuroimaging-genomic fingerprints for subtyping and prediction of Alzheimer's disease and related dementia. The project develops data-driven computational models integrating multi-modal imaging and...
- Project Grant Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $1.73M Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct genetic research on cognitive outcomes related to caloric restriction. The award, effective March 1, 2026 through January 31, 2031, funds a comprehensive research initiative utilizing the Diversity Outbred (DO) mouse model—a systems genetics resource designed to...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $426,250 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026 through January 31, 2028 to conduct a randomized, double-blind, placebo-controlled clinical trial investigating vibegron as a therapeutic intervention for multisystem functional decline in aging and obesity. Vibegron, an FDA-approved beta-3 adrenergic receptor (β3AR) agonist, will be...
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a Project Grant totaling $427,625.00 under the Aging Research program (CFDA 93.866) for the period of February 15, 2026, through January 31, 2028. The award funds research investigating intramuscular adipose tissue (IMAT) quality in aging and its relationship to muscle weakness and physical dysfunction in older adults. The research will deliver scientific findings through two parallel research aims: (1)...
- Federal Grant Award Summary The Buck Institute for Research on Aging received a $809,486 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion scheduled for January 31, 2031. This award supports biomedical research investigating the role of oxidation resistance 1 (OXR1) and retromer proteins in brain aging and Alzheimer's Disease and Related Dementias (ADRD). The research deliverables include...
Wake Forest University Health Sciences received a $3.16 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 1, 2026, through May 31, 2030. The award supports a four-year research initiative investigating the effect of caloric restriction on aging biomarkers, frailty, and multimorbidity in older adults with obesity. The primary research objective is to determine whether short-term caloric restriction affects consensus-derived blood-based biomarkers of biological aging, including interleukin-6, tumor necrosis factor receptor 1, growth differentiation factor-15, cystatin C, C-reactive protein, and insulin. Secondary objectives include measuring the effects of caloric restriction on multimorbidity and deficit accumulation frailty indices in study participants approximately 10 years after intervention completion. The research addresses a critical gap in geroscience by examining whether caloric restriction extends healthspan and lifespan in humans, as previous evidence demonstrates effectiveness in nonhuman primates and other species but remains uncertain in human populations. This longitudinal investigation will generate scientific knowledge regarding the relationship between caloric restriction-induced changes in biological aging biomarkers and overall health outcomes in older adults, potentially informing clinical recommendations for obesity management in aging populations where weight loss benefits and risks remain controversial.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 5/26/26 |