The Johns Hopkins University was awarded a $2,399,582 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to study extracellular vesicles derived from the brain as potential biomarkers for Alzheimer's disease. The 3-year grant, which begins on September 1, 2023, aims to identify specific cell surface markers and molecular signatures on brain-derived extracellular vesicles that could be used for early disease detection, monitoring, and understanding Alzheimer's pathogenesis. Key research activities include testing induced pluripotent stem cell models of neurons, astrocytes, and microglia, as well as analyzing extracellular vesicles from brain tissue and plasma samples. The findings are expected to advance the development of liquid biopsy techniques for assessing central nervous system health and revolutionize the identification and care of Alzheimer's disease.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.4m | 8/18/23 |