This Project Grant award, with Federal Grant ID R01AG089605, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the relationship between α-synucleinopathies (such as Lewy body dementia) and T cell immunity in Alzheimer's disease and related dementias (ADRD). The total award amount is $2,456,497.00, with a project period from August 15, 2024 to April 30, 2029. The primary grantee, The Johns Hopkins University, will utilize the established gut-brain α-synucleinopathy (GBAS) model to examine the progression of these pathologies from the gut to the brain, focusing on the role of the gut-brain axis in ADRD. Additionally, the research team will explore the potential impact of T-cell responses on α-synuclein pathology progression and investigate potential applications of immunotherapy. This collaborative effort aims to enhance the understanding of the complex mechanisms underlying neurodegenerative diseases and develop innovative therapeutic strategies. The project includes two sub-awards: one to the University of Houston System ($338,897 starting January 2025) and another to the University of Texas MD Anderson Cancer Center ($495,302 starting January 2025). These sub-awards will contribute specialized expertise and support to the overall research goals.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $787.1k | 7/7/25 | ||
| Not listed | $0 | 6/17/25 | ||
| Not listed | $0 | 6/17/25 | ||
| Not listed | $834.7k | 8/15/24 | ||
| Not listed | $834.7k | 8/15/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
2006627085S | University Of Houston System | Project Grant R01AG089605 | $359.1k | 1/15/25 | |
2006627086S | The Univeristy Of Texas M.d. Anderson Cancer Center | Project Grant R01AG089605 | $64.8k | 1/9/25 |