Project Grant R01AG089605

Award Date 8/15/24
Completion Date 4/30/29
Dollars Obligated $2.5M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Baltimore, MD 21205, USA
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The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $2,273,637 Project Grant to The Johns Hopkins University to conduct a comprehensive study of plasma and brain lipidomics (lipid profiling) and their associations with Alzheimer's disease (AD), dementia, and cognitive decline. The study will leverage novel Lipidyzer technology to quantify over 1,500 lipid species in plasma samples from 3,868 participants in the Cardiovascular Health...
This Project Grant award from the National Institute on Aging (NIA), part of the Aging Research program (CFDA 93.866), provides $622,086.00 to The Johns Hopkins University to conduct research on the role of the NOD2/RIPK2 signaling pathway in neuroinflammation and neurodegeneration in Alzheimer's disease. The 5-year project aims to elucidate the mechanisms of microglial activation by amyloid-beta oligomers, assess the involvement of the NOD2/RIPK2 pathway, determine the impact of selectively...
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This Project Grant award, with Federal Grant ID R01AG089605, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the relationship between α-synucleinopathies (such as Lewy body dementia) and T cell immunity in Alzheimer's disease and related dementias (ADRD). The total award amount is $2,456,497.00, with a project period from August 15, 2024 to April 30, 2029.

The primary grantee, The Johns Hopkins University, will utilize the established gut-brain α-synucleinopathy (GBAS) model to examine the progression of these pathologies from the gut to the brain, focusing on the role of the gut-brain axis in ADRD. Additionally, the research team will explore the potential impact of T-cell responses on α-synuclein pathology progression and investigate potential applications of immunotherapy. This collaborative effort aims to enhance the understanding of the complex mechanisms underlying neurodegenerative diseases and develop innovative therapeutic strategies.

The project includes two sub-awards: one to the University of Houston System ($338,897 starting January 2025) and another to the University of Texas MD Anderson Cancer Center ($495,302 starting January 2025). These sub-awards will contribute specialized expertise and support to the overall research goals.

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