The Johns Hopkins University was awarded a $2,399,582 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to study extracellular vesicles derived from the brain as potential biomarkers for Alzheimer's disease. The 3-year grant, which begins on September 1, 2023, aims to identify specific cell surface markers and molecular signatures on brain-derived extracellular vesicles that could be used for early disease detection, monitoring, and understanding Alzheimer's...
This Project Grant award, funded by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research to investigate how the APOE genotype affects the production and composition of mitovesicles, a type of extracellular vesicle derived from mitochondria, in the brain. The $2,499,343 award, with a performance period from Sep 1, 2024 to Aug 31, 2027, will be led by the Research Foundation for Mental Hygiene, Inc. (RFMH) at the Nathan S. Kline Institute. The project aims to...
This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
This $306,509 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Captis Diagnostics Inc. aims to develop a technology platform for rapid magnetic isolation of neuronal extracellular vesicles (EVs) from blood plasma samples. The goal is to enable the detection of biomarkers for neurological diseases such as Alzheimer's, Parkinson's, and traumatic brain injury through a minimally invasive liquid biopsy approach. Key activities include developing...
The National Institute on Aging (NIA), under its Aging Research Federal Grant Program (CFDA 93.866), awarded a $154,748 Project Grant to Brigham & Women's Hospital Inc. to develop an ultrasensitive blood-based diagnostic tool for accurately detecting and monitoring Alzheimer's disease (AD). The project aims to engineer a diagnostic pipeline that leverages extracellular vesicles (EVs) and single molecule detection technology to quantify low-abundance AD protein biomarkers, particularly...
This federal Project Grant award of $513,740.00 was provided by the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), to develop a novel exosome-based nano-scavenger (EBNS) for the targeted removal of amyloid-beta (Aβ) proteins associated with Alzheimer's disease (AD) and other amyloid-related disorders. The 3-year project aims to: 1) genetically engineer exosomes to load Aβ-targeting antibodies and Aβ-degrading enzymes; 2) establish isolation and...
This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
This $5,274,018 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The J. David Gladstone Institutes will study the susceptibility and resistance to the detrimental effects of the Apolipoprotein E4 (APOE4) genetic risk factor for Alzheimer's disease. The research aims to characterize neurophysiological, behavioral, and neuropathological differences between new APOE4 mouse lines...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $4,694,672 to North Dakota State University from May 15, 2021 through April 30, 2024. The funding supports research to design a non-viral gene delivery system for delivering an APOE2 plasmid to the brain. Specifically, the university will synthesize and characterize liposomal nanoparticles loaded with chitosan-APOE2 polyplexes and modified with transferrin and cell-penetrating peptides...
The National Institute on Aging (NIA) awarded The Roskamp Institute, Inc. a $682,000 Project Grant (CFDA 93.866 - Aging Research) to investigate the influence of microglial cell depletion and repopulation on aducanumab-induced amyloid-related imaging abnormalities (ARIA) and vascular lesions in APOE4 carriers with Alzheimer's disease (AD). The project aims to utilize microglial ablation and repopulation techniques in EFAD mouse models of AD expressing human APOE isoforms to characterize the...