The Johns Hopkins University has been awarded a $324,698 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to study cell-free DNA as a marker of Alzheimer's disease progression and its role in chronic inflammation. The study will use digital PCR to measure cell-free DNA levels in serum samples from individuals with mild cognitive impairment and normal cognition, and evaluate associations with rates of cognitive decline. Additionally, the research will assess the...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The $794,341 award, effective from January 1, 2025 through December 31, 2029, will be conducted by the University of Illinois in Chicago. The research aims to leverage experimental mouse models, molecular characterization of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the cell-type specific impacts of Alzheimer's disease (AD) pathology within the medial temporal lobe. The $103,304 award, effective August 1, 2024 through July 31, 2025, will utilize advanced viral tracing methods and microscopy imaging to identify and reconstruct 3D entorhinal cortex-CA1 neuron circuits that are susceptible to AD pathology propagation. After...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $442,357 in funding to the Research Foundation of the City University of New York (RFCUNY) for research to elucidate molecular mechanisms underlying the neurodegenerative reprogramming of microglia in Alzheimer's disease. The key objectives are to determine how the integrated stress response pathway triggers chromatin remodeling in microglia, examine how this exacerbates their stressed...
This federal Project Grant award of $614,424 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington aims to investigate the role of microglia, the brain's immune cells, in the early progression of Alzheimer's disease (AD). The key products and services to be delivered under this 2-year award include: Applying novel explainable AI techniques and deep learning methods to single-cell brain data to better define subtle microglial changes and AD-specific...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
This $654,238 Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to investigate the role of senescent cells in brain aging and the development of Alzheimer's disease and related dementias (ADRD). The project aims to generate high-resolution spatial omics data from ADRD brains and mouse models to identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons. The work will be conducted by...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) provides $835,825 to the University of Massachusetts Medical School to conduct research on somatic mutations in Alzheimer's disease. The project aims to analyze patterns of somatic single nucleotide variants, short insertions/deletions, and structural variants in neurons from Alzheimer's disease brains across disease progression. It will also examine how these...
This $107,948 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to enhance understanding of the biological signatures that distinguish subgroups of patients with Alzheimer's disease (AD). The key goals are to: Determine if AD subtypes can be identified solely using magnetic resonance imaging (MRI)-derived features through the application of machine learning algorithms. Integrate epigenetic profiles, including small non-coding RNA expression and DNA...