This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $343,440 to The Johns Hopkins University to conduct research on the role of cell-free DNA in microglial activation and inflammation in Alzheimer's disease. The 5-year award period runs from August 2024 to May 2029.
The key objectives are to examine associations between cell-free DNA levels in serum and microglial activation markers in Alzheimer's disease, as well as study functional...
The Johns Hopkins University was awarded a $2,399,582 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) to study extracellular vesicles derived from the brain as potential biomarkers for Alzheimer's disease. The 3-year grant, which begins on September 1, 2023, aims to identify specific cell surface markers and molecular signatures on brain-derived extracellular vesicles that could be used for early disease detection, monitoring, and understanding Alzheimer's...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
This $866,723 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Johns Hopkins University supports research to integrate high-field post-mortem MRI imaging, histological analysis, and spatial transcriptomic profiling of the entorhinal cortex to better understand the molecular and pathological changes underlying Alzheimer's disease progression. The key objectives are to establish protocols for integrating MRI markers with histological tau pathology,...
This Project Grant award from the National Institute on Aging provides $2,797,356 to the University of Pittsburgh to support research into DNA damage-induced inflammation and its brain-specific consequences from April 15, 2022 through March 31, 2025. The award is being made under the Aging Research program (CFDA 93.866), which aims to further the understanding of aging and age-related diseases.
Specifically, the University of Pittsburgh will conduct research exploring cytoplasmic DNA (cytDNA)...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to provide insights into new mechanisms and identify novel targets to prevent Alzheimer's disease, dementia, and cognitive decline. The $790,242 grant, awarded to The Johns Hopkins University, will leverage novel lipidomics technology to:
Examine the association of plasma lipidomic species with risks of incident Alzheimer's disease, total dementia, and cognitive decline in 3,868 participants in...
This $4.6 million project grant from the National Institutes of Health's National Institute on Aging will fund research at the University of Pittsburgh to develop and validate diagnostic assays for small nucleolar non-coding RNAs (snoRNAs) in human plasma as biomarkers for Alzheimer's disease (AD). Specifically, the grant will support testing and validation of droplet digital PCR assays for snoRNAs SNORD115 and SNORD116 in plasma, investigation of associations between levels of these snoRNAs...
This $1,425,000 project grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into neuronal senescence and inflammation in Alzheimer's disease. The Salk Institute for Biological Studies will study the interaction between cellular senescence and inflammation in induced neurons derived from Alzheimer's patients and healthy aged controls. Researchers will examine differences in gene expression and epigenetic...
The National Institute on Aging (NIA) awarded a $885,006 Project Grant under the Aging Research program (CFDA 93.866) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Inc., to develop a smartphone-based point-of-care diagnostic system capable of detecting Alzheimer's disease (AD) biomarkers in blood plasma within 30 minutes. The system will leverage microfluidics, nanotechnology, optical sensing, and deep learning to detect levels of amyloid-beta,...