Project Grant RC2DK144819
- This federal Project Grant award in the amount of $787,367 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by the University of Pennsylvania to map the gene regulatory architecture of pancreatic islet-specific cell types and improve the understanding of diabetes pathogenesis. The key objectives are to: 1) create the largest map...
- This $882,180 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to The Broad Institute, Inc. aims to conduct a massive-scale genomic risk assessment to inform precision medicine across the spectrum of monogenic and common forms of diabetes. The project will analyze the largest ever dataset of rare variation linked to diabetes phenotyping, comprising over 1.1M participants (33%...
- This federal Project Grant award of $248,915 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to unravel the role of epigenetics and cytokines in type 2 diabetes (T2D) among African-ancestry populations. The research is being conducted by the University of Maryland, Baltimore, with the goal of inferring causality between DNA methylation, circulating...
- This $641,794 Project Grant was awarded on July 21, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by the Beckman Research Institute of the City of Hope to elucidate the mechanisms that protect pancreatic beta-cells from DNA damage during periods of growth and adaptation, in order to maintain beta-cell homeostasis and address the...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,408,665 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of North Carolina at Chapel Hill (UNC-CH). The grant, awarded on December 20, 2024, will support research to identify mechanisms by which the drug metformin regulates T cell responses in obesity. The project aims to understand T cell dysfunction in obesity and explore novel...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $843,485 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Duke University. The grant, running from September 2025 to August 2030, will assess the impact of two novel, population-tailored health insurance designs on diabetes outcomes for approximately 1.75 million working-age adults. The project aims to evaluate whether providing more generous...
- This federal Project Grant award of $455,491.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program, supports research on the role of T follicular helper cells (Tfh) in regulating T cell-mediated type 1 diabetes (T1D). The research will be conducted by the University of North Carolina at Chapel Hill (UNC-CH) from August 1, 2025 to May 31, 2030. The key objectives are to...
- This $3,140,632 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to elucidate the mechanisms underlying human endocrine lineage commitment and harness this knowledge to improve strategies for beta cell replacement in diabetes treatment. The long-term objectives are to generate in vitro-derived beta cells that recapitulate endogenous function, which could lead to...
- This $451,000 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the role of microRNAs in adipose tissue from people with HIV who develop type 2 diabetes. The project aims to evaluate microRNA expression in adipose tissue samples and explore whether circulating microRNAs could serve as novel biomarkers of...
- The federal Project Grant award of $804,342.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at Duke University focused on understanding the complex metabolic actions of the hormone glucagon beyond its canonical role in preventing hypoglycemia. The research aims to elucidate how glucagon receptor signaling in hepatocytes engages divergent pathways...
This $1,620,238 project grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The University of North Carolina at Chapel Hill will use the funding to provide resources to detect regulatory variants and elements at Type 2 diabetes genome-wide association study (GWAS) signals across disease-relevant tissues including pancreatic islets, adipose, skeletal muscle, and liver. The goal is to prioritize variants and genes for in-depth mechanistic studies, risk prediction, and identification of drug targets, with a focus on understanding the role of mitochondrial dysfunction in multiple tissues involved in Type 2 diabetes pathogenesis. The project will run from September 2025 through June 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 9/19/25 |