Project Grant R01DK141090
- This federal Project Grant award of $803,748 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is funding research to investigate the modulation of insulin signaling in adipocytes (fat cells) and how improved adipocyte insulin sensitivity can contribute to positive metabolic outcomes. The research team at The University of Texas Southwestern Medical...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $773,112 Project Grant to Rockefeller University on September 5, 2025 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the mechanisms of transcriptional control in adipocyte formation and function through nuclear receptor coactivators. The research aims to provide a better understanding of dysregulation in energy storage...
- This federal Project Grant award of $776,568.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research conducted by Duke University to investigate the regulation of adipose tissue plasticity by pericyte glucose-dependent insulinotropic polypeptide receptor (GIPR). The key objectives are to: 1) Identify the principal GIPR-expressing cell type in adipose tissue, 2) Determine the role...
- This Project Grant award, with $1,331,148 in funding from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the mechanisms of islet cell compensation for beta-cell mass deficiency in type 2 diabetes. The research aims to determine the signaling pathways through which increased glucagon secretion from pancreatic alpha-cells helps preserve...
- This $769,097 Project Grant was awarded on September 5, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Pennington Biomedical Research Center in Baton Rouge, Louisiana to investigate a novel brain-to-pancreatic islet neural circuit that regulates glucose homeostasis. The research aims to establish the physiological...
- This federal Project Grant award of $737,034.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of this 5-year research project, with a start date of September 1, 2025, is to identify new regulatory inputs that control the biosynthesis of coenzyme A (CoA) in response to the metabolic state of cells and tissues, especially the kidney and liver. The...
- This federal Project Grant award of $194,966 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a research project led by Dr. Joshua Cook at Columbia University's Health Sciences Division to investigate the pathophysiology of selective insulin resistance in humans. Specifically, the project aims to demonstrate that high insulin levels continue...
- This $2,971,227 federal Project Grant, awarded on September 4, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of fatty acids in regulating cellular metabolism and protein synthesis in the context of fasting, inflammation, and metabolic diseases. The research aims to uncover novel signaling pathways through which fatty...
- This federal Project Grant award of $122,454, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of the GIMAP5 gene in maintaining liver homeostasis. The primary recipient, Yale University, is conducting studies to determine how loss of function in the GIMAP5 gene leads to capillarization and dedifferentiation of liver...
- The University of Kentucky Research Foundation was awarded a $538,354 Project Grant by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) on June 17, 2025. The grant will fund research to investigate the role of the hypothalamic adhesion G-protein coupled receptor L 1 (ADGRL1) in mediating the counterregulatory response to hypoglycemia. The project aims to establish the contribution of ADGRL1 in the ventromedial nucleus of the hypothalamus to eliciting the...
This $804,342 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Duke University to investigate the metabolic actions of glucagon, a hormone that plays a key role in glucose regulation. Specifically, the research aims to characterize how glucagon receptor signaling in the liver engages divergent pathways that differentially impact glucose metabolism, including enhancing insulin sensitivity in addition to the canonical pathway of increasing endogenous glucose production. The project will employ complementary physiological and pharmacological approaches in mouse models as well as parallel experiments in human subjects to advance the understanding of glucagon's multifaceted metabolic functions beyond its traditional role in hypoglycemia prevention. The award period extends from September 1, 2025 through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $804.3k | 9/1/25 |