This federal Project Grant award of $444,867.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research will use a novel mouse model to elucidate the pathological role of XBP1s in beta cell integrity under metabolic stress, in order to...
This federal Project Grant award of $706,199 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to uncover the mechanisms of NAD depletion in obesity-induced pancreatic beta cell dysfunction and test strategies to restore beta cell mass and function in type 2 diabetes models. The award aims to define changes in NAD biosynthesis and degradation pathways...
This Project Grant award of $847,746 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of the UPR transducer XBP1 in pancreatic beta cell survival and function under metabolic stress. The research aims to elucidate the impact of XBP1S overexpression on beta cell integrity and the potential mechanisms underlying dynamic beta cell...
This $698,646 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to study the functional and disease relevance of distinct pancreatic beta-cell subtypes, with a focus on understanding their epigenetic regulation and relationship to type 2 diabetes (T2D). The research will use novel single-cell epigenomic tools, conditional...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at Brigham Young University to determine the role of the NR4A1 gene in pathways that expand functional beta cell mass as a potential treatment for type 1 and type 2 diabetes. The $568,075 award, with a project period from Jul 1, 2025 to Jun 30, 2028, will fund studies to...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the molecular mechanisms by which the bacterial protein Beta-cell Expansion Factor A (BEFA) induces proliferation and metabolic maturation of pancreatic beta cells. The $146,829 award, effective from June 2025 through December 2027, will be used by the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $133,249 to the University of Alabama at Birmingham to investigate the role of the RNF20 histone modifier in pancreatic beta cell function and senescence. The research aims to elucidate the regulatory relationship between RNF20 and the CDKN2A locus to assess whether RNF20 mediates...
This Project Grant award of $223,176 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports a training and research program led by Dr. Rebecca Davidson at the University of Michigan. The goal is to investigate the role of mitochondrial DNA damage in beta-cell dysfunction and failure in diabetes. The program will provide Dr. Davidson with hands-on training in molecular,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $174,368 to the Regents of the University of Michigan to support a research project focused on understanding the role of the LRRK2 kinase in pancreatic beta cell responses to inflammatory damage. The goal is to gain insights into the molecular mechanisms that govern beta cell survival under inflammatory conditions, which could inform new therapeutic approaches for treating...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,349,491 to The Trustees of the University of Pennsylvania to conduct research on reprogramming glutamine metabolism in pancreatic beta cells. The research aims to uncover the mechanisms by which the transaminase GPT2 promotes beta cell dysfunction and death, and elucidate how GPT2...