Project Grant R01DK140088

Award Date 7/21/25
Completion Date 4/30/30
Dollars Obligated $642K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
California, USA
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This Project Grant award, ID R01DK140088, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $641,794 grant awarded to the Beckman Research Institute of the City of Hope will fund research to elucidate the mechanisms that protect pancreatic beta cells from DNA damage during growth and adaptation, in order to maintain beta cell homeostasis and prevent beta cell failure in diabetes. The research aims to establish the role of the cohesin complex in regulating beta cell growth, maturation, and stress adaptation using mouse genetics, human islet studies, live-cell imaging, and genomic profiling methods. This work is expected to provide novel insights into the roots of beta cell failure and how early life events influence diabetes risk, potentially leading to improved strategies for beta cell rejuvenation and replacement to advance diabetes therapy.

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