Project Grant R21DK145238
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,778,953 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Minnesota. The award, with a start date of September 16, 2025 and a completion date of June 30, 2029, will support research on the dynamics of the HIV reservoir and its association with metabolic complications of HIV infection in individuals receiving...
- This Project Grant award of $248,915 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to unravel the role of epigenetics and cytokines in type 2 diabetes among African-ancestry populations in the U.S. and Europe. The research aims to identify causal associations between DNA methylation, circulating cytokines, and diabetes risk in these populations...
- This $2,971,227 federal Project Grant, awarded on September 4, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of fatty acids in regulating cellular metabolism and protein synthesis in the context of fasting, inflammation, and metabolic diseases. The research aims to uncover novel signaling pathways through which fatty...
- This $1,554,672 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to define the molecular mechanisms underlying gut inflammation and barrier dysfunction in people living with HIV. The grant supports research led by The Washington University in Missouri to establish a novel humanized mouse model that can faithfully recapitulate HIV infection in...
- This $291,949 Project Grant was awarded on September 15, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant was awarded to Biosettia Inc. (UEI: GZM5S2UYEGD2) located in San Diego, CA to support research aimed at using deep sequencing to measure variants of the endogenous retrovirus (ERV) GAG gene as potential biomarkers for type 1 diabetes. The project seeks...
- This $786,216 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on post-transcriptional regulation of hepatokines and their impact on systemic metabolism. The University of California, Los Angeles is conducting this research to investigate a novel mechanism by which the liver uses RNA-binding proteins to control the...
- This federal Project Grant award of $1,620,238 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund a research project at the University of North Carolina at Chapel Hill (UNC-CH) to detect regulatory variants and elements at type 2 diabetes genetic association signals across multiple tissues, including pancreatic islets, adipose, skeletal...
- This federal Project Grant award of $803,748 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is funding research to investigate the modulation of insulin signaling in adipocytes (fat cells) and how improved adipocyte insulin sensitivity can contribute to positive metabolic outcomes. The research team at The University of Texas Southwestern Medical...
- This Project Grant award of $107,948 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund research at Case Western Reserve University (CWRU) to investigate the role of microRNA146a (miR146a) in regulating autoimmunity in Type 1 Diabetes (T1D). The project aims to study how miR146a deficiency impacts T cell autoreactivity and T regulatory cell...
- This $780,853 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) aims to investigate the impact of a glucagon-like peptide-1 receptor agonist on simian immunodeficiency virus (SIV)/human immunodeficiency virus (HIV) pathogenesis and antiretroviral therapy (ART) administration in people living with HIV. The project, to be conducted by the University of Pittsburgh from April 2025 through March 2030, will assess changes in T-cell and...
This $451,000 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research to investigate the role of microRNAs in adipose tissue from people with HIV who develop type 2 diabetes. The project aims to evaluate microRNA expression in adipose tissue and explore whether circulating microRNAs in plasma could serve as biomarkers of risk for type 2 diabetes in this population. Findings from this research have the potential to inform future studies on molecular targets to mitigate the impact of HIV on adipose tissue physiology and type 2 diabetes risk. The award period is from September 5, 2025 to August 31, 2027, and the work will be conducted by The Regents of the University of California, San Francisco.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 9/4/25 |