Project Grant R01DK139107
Award Date
12/20/24
Completion Date
11/30/29
Dollars Obligated
$1.4M
Similar Awards
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $4,366,195 to the University of Alabama at Birmingham (UAB) to conduct a placebo-controlled, randomized clinical trial assessing the ability of the drug metformin to mitigate inflammation and improve vaccine responses in people with a history of injection drug use, including those with and without HIV. The research aims to determine metformin's...
This federal Project Grant award of $796,760 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Program (CFDA 93.837) supports research to investigate the protective effects of metformin, a diabetes medication, against cigarette smoke-induced lung damage. The overarching goal is to understand how metformin can improve the function of alveolar type 2 (AT2) epithelial cells, which are crucial for maintaining lung health and promoting...
This Project Grant award of $659,199 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate a novel pathway by which hepatocyte-derived GDF15 improves obesity-associated insulin resistance independent of body weight loss and GDF15 receptor signaling. The research aims to characterize the structural basis and functional consequences of GDF15...
This Project Grant award of $532,177 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate a new inflammation pathway in diabetic kidney disease (DKD). The University of North Texas Health Science Center at Fort Worth will conduct in vitro and in vivo studies to: 1) determine how the transcription modulator I-MFA stimulates inflammatory cytokine production in...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to study the regulation of metabolic diseases by the human commensal bacterium Clostridium immunis. The overarching goal is to determine the mechanism by which an exopolysaccharide (EPS) secreted by C. immunis decreases visceral adiposity, a key risk factor for type 2 diabetes and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $516,648 to The Leland Stanford Junior University (Stanford University) to conduct research on understanding how microbially-derived metabolites regulate host gut inflammation. The key objectives of this 2.5-year project are to: 1) determine the regulatory role of these microbial metabolites on the host immune...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $1,041,906 in funding to the Regents of the University of Michigan to investigate the role and mechanism of the UNC119B protein in regulating glucose homeostasis and its potential as a target for treating type II diabetes. The key objectives are to: 1) determine the importance of UNC119B in glucose storage tissues...
This Project Grant award of $1,328,326.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the regulation of CD39 expression in gamma delta intraepithelial lymphocytes (gd IELs) and its impact on immunometabolism and function. The research aims to elucidate the mechanisms by which CD39 expression is regulated in gd IELs, understand the coupling between CD39 and gd IEL...
This $174,368 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a research project led by Belle Henry, a Ph.D. candidate at the University of Michigan. The project aims to investigate the role of the LRRK2 kinase in pancreatic beta cell responses to inflammatory damage, with a focus on understanding how LRRK2 regulates mitophagy to promote beta cell survival. The...
This $578,060 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to study a potential new enhancer region that activates the UCP1 gene, which is critical for thermogenesis and energy expenditure. The research will examine how this enhancer functions to increase UCP1 transcription, as well as assess its impact on thermogenesis, adiposity, and...