Project Grant R01DK144744
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $153,554 Project Grant to the Beckman Research Institute of the City of Hope. This grant, awarded on September 15, 2025, supports research aimed at unveiling novel targets for type 1 diabetes therapy by investigating the functional heterogeneity of pancreatic alpha cells and their interactions with beta and delta...
- This $2,263,983 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to develop "engineered regulatory T cells (Tregs)" as an immunotherapy for type 1 diabetes. The central goal is to create antigen-specific Tregs that can more effectively suppress the autoimmune destruction of insulin-producing beta cells. The research...
- This federal Project Grant award of $1,620,238 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund a research project at the University of North Carolina at Chapel Hill (UNC-CH) to detect regulatory variants and elements at type 2 diabetes genetic association signals across multiple tissues, including pancreatic islets, adipose, skeletal...
- This federal Project Grant award of $801,662, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research by the Scripps Research Institute to investigate the early phase of type 1 diabetes. The key objectives are to characterize the antigen-presenting cells associated with pancreatic islets during the pre-diabetic stage in mice, using advanced techniques...
- This Project Grant award of $107,948 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund research at Case Western Reserve University (CWRU) to investigate the role of microRNA146a (miR146a) in regulating autoimmunity in Type 1 Diabetes (T1D). The project aims to study how miR146a deficiency impacts T cell autoreactivity and T regulatory cell...
- The University of California, Davis received a $126,480 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to conduct research on the role of the signaling protein 14-3-3-z in regulating the crosstalk between pancreatic islet cells. The research aims to define a new pathway regulating 14-3-3-z expression in beta cells and investigate how this impacts alpha cell function and glucose-stimulated insulin secretion. This project is expected...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $235,403 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Johns Hopkins University. The funding will support the development of a membrane-reconstituted ZNT8 biosensor to detect cell-surface ZNT8 autoantibodies in the peripheral blood of patients with type-1 diabetes. This novel bioanalytical tool aims to enable the early detection of islet...
- This federal Project Grant award of $568,075.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award to Brigham Young University aims to determine the role of the transcription factor NR4A1 in the pathways that expand functional beta cell mass, which is critical for treating type 1 and type 2 diabetes. The research seeks to understand how NR4A1 is...
- This $532,177 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), supports research to investigate a novel inflammatory pathway in diabetic kidney disease (DKD). The research aims to elucidate the role of the transcription modulator I-MFA in regulating inflammatory cytokine production by glomerular mesangial cells, a key contributor to DKD pathogenesis. The 4-year project at the University of North Texas Health Science Center will...
- This federal Cooperative Agreement award of $1,786,925.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of inefficient RNA editing in triggering an innate immune response that leads to beta cell death and the development of type 1 diabetes. The award will fund a project led by the University of Pennsylvania to evaluate...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $455,491 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of North Carolina at Chapel Hill. This grant will fund a 5-year research project to investigate the role of T follicular helper cells (Tfh) in regulating T cell-mediated autoimmunity in type 1 diabetes. The research aims to characterize changes in islet Tfh as the disease progresses, define how islet Tfh regulate B cell autoimmunity, and examine the diabetogenic potential of different Tfh subsets. The findings are expected to provide novel insights into the properties and mechanisms of Tfh and regulatory Tfh cells in type 1 diabetes pathogenesis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $455.5k | 7/31/25 |