Project Grant R61MH143792
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded J. David Gladstone Institutes a Project Grant totaling $2,177,199 under the Mental Health Research Grants program (CFDA 93.242), effective September 1, 2025, through August 31, 2027. This two-phase, milestone-driven research initiative aims to develop and validate a novel humanized microglia-neural cell (HUMGN) mouse model that incorporates human microglia, neurons, and astrocytes differentiated from induced...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a $1.1 million Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective May 1, 2026, through January 31, 2031. This research initiative investigates the effects of broadly neutralizing antibodies (BNAbs) on neuroinflammation and central nervous system (CNS) persistence in simian immunodeficiency virus (SIV)-infected, antiretroviral therapy (ART)-treated...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded Modulo Bio, Inc. a $1.48M Project Grant (CFDA 93.242—Mental Health Research Grants) effective March 1, 2026, through February 29, 2028, to develop an artificial intelligence (AI)-guided triculture platform for modeling HIV-associated brain injury (HABI) under antiretroviral therapy (ART) suppression. The platform will integrate induced pluripotent stem cell (iPSC)-derived microglia, astrocytes, and neurons to...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a Project Grant of $149,190 under the Mental Health Research Grants program (CFDA 93.242) on August 2, 2026, with a completion date of February 1, 2027. This award funds research identifying intervention opportunities to prevent and mitigate cognitive impairment among people aging with HIV (PWH). The project delivers two primary research outputs: (1) quantitative analysis estimating...
- Federal Grant Award Summary Rush University Medical Center received a $1.52M Project Grant from the National Institute of Mental Health under the Mental Health Research Grants program (CFDA 93.242), effective April 1, 2026 through March 31, 2028. The grant funds research utilizing a human-mouse chimera model to investigate the dynamics of HIV infection in the central nervous system. The research will assess the interactions between brain cells and peripheral immune cells in vivo using an...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Alabama at Birmingham a $409,750 Project Grant under the Mental Health Research Grants program (CFDA 93.242) beginning March 15, 2026, with a completion date of March 14, 2028. This research project, titled "Determining the Role of Localized Dopamine Signals in Learning," will deliver fundamental neuroscience research investigating how dopamine—a critical neuromodulator involved in...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded Icahn School of Medicine at Mount Sinai a $3.6M Project Grant under the Mental Health Research Grants program (CFDA 93.242) on September 22, 2025, with a completion date of September 21, 2029. This research project, titled "Targeting the NLRP3 Inflammasome to Mitigate Neuroinflammation and HIV Persistence in the CNS: Mechanisms and Therapeutic Strategies," investigates the role of the NLRP3...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded $837,097 to The University of Texas Southwestern Medical Center on September 22, 2025, under the Mental Health Research Grants program (CFDA 93.242) to conduct a five-year imaging study examining microglia proliferation and its relationship to cognitive control deficits in virally-suppressed people with human immunodeficiency virus (VS+PWH). The project, extending through May 31, 2030, utilizes positron...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $698,390 to the Regents of the University of California at Riverside on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This Project Grant supports a five-year research initiative (completion date June 30, 2030) focused on harnessing innate immunity to control the neuroinflammatory human immunodeficiency...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $759,816 Project Grant to the University of California, Berkeley effective May 1, 2026, through January 31, 2031, under the Mental Health Research Grants program (CFDA 93.242). This award supports research on "Targeted Machine Learning to Evaluate and Optimize HIV Prevention Strategies in Cluster Randomized Trials." The project will develop, apply, and disseminate new targeted machine learning...
The National Institute of Mental Health (NIMH) awarded the University of Alabama at Birmingham a $1.81 million Project Grant (CFDA 93.242: Mental Health Research Grants) on June 5, 2026, with completion targeted for June 4, 2028. This award supports the development of novel preclinical neurohuman immunodeficient mouse models designed to advance understanding of HIV-associated neurocognitive dysfunction in the central nervous system (CNS). The primary deliverable is a next-generation neuroHIV model that integrates autologous peripheral human immune cells, multiple relevant human glial cell types, and an intact blood-brain barrier, specifically engineered to simulate chronic infection dynamics under antiretroviral therapy (ART) suppression. The research addresses a critical gap in existing preclinical models, which have primarily focused on acute HIV infection rather than chronic, ART-suppressed conditions that persist in 30-50% of people living with HIV. By incorporating human CNS-immune cell interactions and accurately representing the effects of long-term viral suppression, the models generated through this project are expected to yield insights into HIV-associated neurocognitive disorder and inform future therapeutic development. The project integrates advances in humanized immunodeficient mouse technology with comprehensive human cell populations to better replicate the complex neuroimmune environment relevant to clinical HIV disease.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.8m | 6/9/26 |