Project Grant R01MH141671
- Federal Grant Award Summary The National Institute of Mental Health awarded a $149,190 Project Grant to The Johns Hopkins University on August 2, 2026, under the Mental Health Research Grants program (CFDA 93.242). The project, "Identifying Intervention Opportunities in the Continuum of Cognitive Impairment Among Persons Aging with HIV," will deliver research products addressing cognitive impairment prevention and mitigation strategies for people aging with HIV (PWH). Aim 1 will...
- Federal Grant Award Summary The National Institute of Mental Health awarded Johns Hopkins University $733,314 under the Mental Health Research Grants program (CFDA 93.242) on September 23, 2025, to optimize measurement and evaluate health impacts of stigma among populations at risk for and living with HIV (PLHIV). The project, extending through August 31, 2030, will enhance the PLHIV Stigma Index platform by integrating validated social, behavioral, and economic (SBE) stigma assessment...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $837,097 Project Grant to The University of Texas Southwestern Medical Center on September 22, 2025, under the Mental Health Research Grants program (CFDA 93.242) to support research on imaging microglia in virally-suppressed people with HIV (VS+PWH). The project, extending through May 31, 2030, investigates the relationship between microglial proliferation and cognitive control deficits in VS+PWH using advanced...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a Project Grant of $104,349.00 under the Mental Health Research Grants program (CFDA 93.242) for the period April 1, 2026 through March 31, 2028. The project, titled "Attentional Modulation of Neural Activity in Multi-Attribute Decision Making," investigates how attention influences neural processing during complex decision-making involving multiple attributes. The research...
- Federal Grant Award Summary Rush University Medical Center received a $1.52 million Project Grant from the National Institute of Mental Health under the Mental Health Research Grants program (CFDA 93.242), awarded April 1, 2026, with a completion date of March 31, 2028. This research initiative develops a human-mouse chimera model to investigate the dynamics of HIV infection in the brain and its neurological consequences. The project generates scientific knowledge regarding how HIV-infected...
- Federal Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $431,750 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) awarded May 15, 2026, with completion targeted for May 14, 2028. The grant funds a two-year research project investigating the role of DNA-dependent protein kinase (DNA-PK) in regulating Human Immunodeficiency Virus (HIV) latency within the central...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a Project Grant of $443,931 under the Mental Health Research Grants program (CFDA 93.242) for the period July 1, 2025 through June 30, 2027. This research project aims to develop and validate novel methodologies for accurately tracking structural brain changes using low-field (0.05T) magnetic resonance imaging (MRI) technology coupled with autonomous control systems and...
- Federal Grant Award Summary Yale University received a $491,700 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded September 3, 2025, with completion targeted for September 2, 2027. The project investigates the role of cerebrospinal fluid (CSF) memory B cells in neuroinflammation and cognitive impairment among people with HIV (PWH) on antiretroviral therapy (ART). The research will generate monoclonal...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a $1,504,616 Project Grant on June 12, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate the relationship between N-acetyl-aspartyl-glutamate (NAAG) and memory deficits in schizophrenia patients in mid- to late-life. The research addresses a critical gap in understanding cognitive dysfunction, which is a core feature of schizophrenia that...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a Project Grant of $197,640 under the Mental Health Research Grants program (CFDA 93.242), effective September 1, 2025 through August 31, 2030. This award supports an early-career investigator's research into the functional consequences of schizophrenia-associated genetic variants in GRIA3, a gene encoding the GluA3 subunit of the AMPA receptor...
The National Institute of Mental Health (NIMH) awarded The Johns Hopkins University a $1.1 million Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective May 1, 2026 through January 31, 2031. This research grant supports a five-year investigation into the effects of broadly neutralizing antibodies (BNAbs) on neuroinflammation and central nervous system (CNS) persistence in simian immunodeficiency virus (SIV)-infected antiretroviral therapy (ART)-suppressed macaques. The project addresses a critical gap in understanding persistent cognitive impairment in people with HIV despite viral suppression through combination therapy of BNabs and ART, utilizing the SIVmac251 rhesus macaque model to assess whether BNab therapy reduces neuroinflammation, decreases CNS viral reservoir size, and improves cognitive function. The research deliverables include mechanistic investigations of how BNab therapy affects CNS inflammation and HIV persistence, quantitative assessments of cognitive outcomes in the animal model, characterization of direct and indirect anti-inflammatory effects of BNab treatment, and scientific publications advancing knowledge of therapeutic interventions for HIV-associated neurocognitive disorders. This funding represents the first dedicated NIH investigation examining BNab therapy in combination with ART specifically for neuroinflammation reduction and cognitive improvement, filling a significant research need identified across 50+ ongoing BNab clinical trials.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.1m | 5/7/26 |