Project Grant RF1MH141600
- This federal Project Grant award of $678,674, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to identify the molecular mechanisms triggering the activation of intracellular innate immunity in microglia and characterize the cellular crosstalk between HIV-infected and non-infected cells in the brain under combination antiretroviral therapy (cART) conditions. The primary objective is to understand how the activation...
- The Project Grant award of $698,390, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), supports research to harness innate immunity to control the neuroinflammatory HIV reservoir. The research aims to investigate how HIV-1 infection triggers an interferon (IFN) response and how IFN-β can be used in conjunction with combined anti-retroviral therapy (cART) to restrict...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) seeks to develop a next-generation preclinical model of NeuroHIV that better recapitulates neuro-immune-vascular system interactions in the context of ART-mediated HIV suppression. The $1,025,015 award to the Scintillon Institute, a non-profit biomedical research organization in San Diego,...
- This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the role of cerebrospinal fluid (CSF) memory B cells in HIV-associated neuroinflammation and cognitive impairment. The $491,700 award to Yale University, made on September 3, 2025, will fund a 2-year study to generate monoclonal antibodies from CSF-derived memory B cells and screen them for reactivity against HIV,...
- This $2,177,199 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, is supporting the development and characterization of a novel mouse model for studying the impact of HIV and addictive substances on the central nervous system (CNS). The key objectives are to establish a "chimeric humanized microglia-neural cell (HUMGN) mouse model" that incorporates human microglia, neurons, and astrocytes derived...
- This federal Project Grant award of $194,375.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding supports research to evaluate the contribution of HIV in the central nervous system (CNS) to associations with inflammation, brain structure, function, and cognition in people living with HIV. Specifically, the research aims to determine if...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $192,268 to the Icahn School of Medicine at Mount Sinai to investigate the effects of proposed HIV cure strategies in the gut-associated lymphoid tissue. The project aims to evaluate the gut-specific impacts of strategies to eliminate the HIV viral reservoir, which is largely located in the gut. Led by Dr. Francesca Cossarini, an Assistant...
- The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
- The National Institute of Mental Health (NIMH) awarded a $837,097 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The University of Texas Southwestern Medical Center in Dallas, Texas. The grant, awarded on September 22, 2025, aims to study the relationship between regional proliferation of microglia, a type of brain cell, and cognitive function impairment in virally-suppressed people with HIV. The project will utilize Positron Emission Tomography (PET) imaging...
- This federal Project Grant award from the National Institutes of Health National Institute of Mental Health provides $6,499,884 to Yale University under the Mental Health Research Grants program (CFDA 93.242) to study the longitudinal nervous system consequences of SARS-CoV-2 in people with HIV-1 treated in early infection. The award will fund research from September 2022 to September 2025 to analyze pre- and post-COVID-19 data from a cohort of early antiretroviral therapy-treated people with...
This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $3,613,504 to the Icahn School of Medicine at Mount Sinai to investigate the role of the NLRP3 inflammasome in HIV-induced neuroinflammation and its impact on HIV persistence in the central nervous system (CNS). The 4-year project aims to: 1) elucidate the link between HIV-1 infection and NLRP3 inflammasome activation in the CNS using brain organoid and humanized mouse models, 2) examine how inflammasome activation influences the establishment and maintenance of HIV latency in the CNS, and 3) develop and evaluate therapeutic strategies to mitigate neuroinflammation and HIV persistence. The research team's expertise in HIV biology, inflammasome pathways, CNS model systems, and data analysis positions them to address this critical knowledge gap and advance the understanding of persistent HIV reservoirs and neuroinflammation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($20k) | 9/24/25 | ||
| Not listed | $3.6m | 9/22/25 |