Project Grant R01MH138164
- The National Institute of Mental Health (NIMH) awarded a $985,984 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. (HJF) to determine the interplay between mucosal-associated invariant T (MAIT) cells and the translocated microbiome in HIV-induced neuroinflammation. The key objectives are to longitudinally compare the relationships between the gut microbiome, MAIT cells in cerebrospinal...
- This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research to investigate the role of cerebrospinal fluid (CSF) memory B cells in HIV-associated neuroinflammation and cognitive impairment. The $491,700 award to Yale University, made on September 3, 2025, will fund a 2-year study to generate monoclonal antibodies from CSF-derived memory B cells and screen them for reactivity against HIV,...
- The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
- This federal Project Grant award, totaling $745,822.00 and provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate the role of the PERK kinase in HIV-induced neuroinflammation and neurocognitive impairment (NCI) in people with HIV (PWH). The University of Pennsylvania, as the primary grantee, will use biochemical, cellular, and pharmacologic approaches to assess PERK's potential as a predictive...
- This $2,177,199 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, is supporting the development and characterization of a novel mouse model for studying the impact of HIV and addictive substances on the central nervous system (CNS). The key objectives are to establish a "chimeric humanized microglia-neural cell (HUMGN) mouse model" that incorporates human microglia, neurons, and astrocytes derived...
- This $246,000 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will support research at The University of Texas Southwestern Medical Center (UT Southwestern) to investigate age-dependent dysfunction in the dentate gyrus (DG) region of the hippocampus and its relationship to the pathophysiology of psychosis. The research aims to reverse-translate discoveries from post-mortem human brain analyses, specifically...
- The National Institute of Mental Health (NIMH) awarded a $314,113 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Physical Sciences Inc. (PSI) of Andover, MA. The grant will fund the development and demonstration of a high-speed, multicolor confocal fluorescence imager to simultaneously capture multi-wavelength signals and display them as separated or merged multicolor images and 3-D stacks. This technology innovation will enable mapping of complex neuronal network...
- This federal Project Grant award of $678,674, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to identify the molecular mechanisms triggering the activation of intracellular innate immunity in microglia and characterize the cellular crosstalk between HIV-infected and non-infected cells in the brain under combination antiretroviral therapy (cART) conditions. The primary objective is to understand how the activation...
- The University of Texas at Dallas (UTD) was awarded a $821,998 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program. The grant, awarded on April 15, 2025, supports a comprehensive research initiative to enhance the delivery of non-viral, neuron-specific molecules across multiple species in the central nervous system (CNS). The key objectives are to further characterize the range of molecules that can be delivered by a...
- This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $3,613,504 to the Icahn School of Medicine at Mount Sinai to investigate the role of the NLRP3 inflammasome in HIV-induced neuroinflammation and its impact on HIV persistence in the central nervous system (CNS). The 4-year project aims to: 1) elucidate the link between HIV-1 infection and NLRP3 inflammasome activation in the CNS using brain organoid and humanized...
The National Institute of Mental Health (NIMH) awarded a $837,097 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The University of Texas Southwestern Medical Center in Dallas, Texas. The grant, awarded on September 22, 2025, aims to study the relationship between regional proliferation of microglia, a type of brain cell, and cognitive function impairment in virally-suppressed people with HIV. The project will utilize Positron Emission Tomography (PET) imaging techniques to localize and quantify the expression of microglial markers, with a focus on the Colony Stimulating Factor 1 Receptor (CSF1R), in brain regions associated with executive function and cognitive control. The findings are expected to enhance the understanding of neuroinflammatory processes underlying cognitive complications in this patient population, potentially informing the development of targeted interventions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $837.1k | 9/22/25 |