Project Grant R01NS148274
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,025,015 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Scintillon Institute in California. The grant, awarded on August 11, 2025, supports the development of a next-generation preclinical model of NeuroHIV that better recapitulates the neuro-immune-vascular system interactions in the context of antiretroviral therapy-mediated HIV suppression....
- This federal Project Grant award of $601,307 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research to elucidate the mechanism by which HIV-1 downregulates specific RNA modifications (YW, DPH, and M1ACP3Ps) that normally repress ribosomal frameshifting on HIV-1 mRNA. The research aims to determine how this deregulation of RNA...
- This Project Grant award, valued at $184,506.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the dual role of amyloid beta (Aβ) in the neuropathogenesis of HIV-associated neurocognitive disorder (HAND). Specifically, the project aims to explore how Aβ influences HIV entry into the central...
- This federal Project Grant award of $194,375.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), aims to determine the impact of persistent HIV in the central nervous system (CNS) on inflammation, brain structure and function, and cognition in people living with HIV. The primary goals are to: 1) Evaluate the specific contribution of HIV in the CNS to...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of the CCL2/CCR2 signaling pathway in modulating HIV-associated ischemic stroke severity and recovery. The $422,125 award, effective from September 18, 2024 to August 31, 2026, will be conducted by the University of Miami. The research aims to...
- This federal Project Grant award, worth $382,072, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to investigate the epigenetic mechanisms underlying HIV-associated neurocognitive disorders (HAND), which remain a significant complication of HIV infection despite antiretroviral therapy. The research will focus on characterizing the...
- This Project Grant award of $437,250.00 from the National Institutes of Health (NIH) under the Trans-NIH Research Support (CFDA 93.310) program supports research to investigate the roles of specific CD4 T cell subsets, namely T helper 1 (Th1) cells and T central memory (TCM) cells, in driving neuroinflammation associated with HIV. The research aims to assess the impact of blocking the infiltration of these CD4 T cell subsets into the central nervous system (CNS) to reduce viral loads and...
- This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of California, Irvine (UCI). The $471,159 grant supports research to elucidate the mechanisms of local axonal responses to interferon lambda (IFN-L) and their effects on the invasion of the nervous system by alpha herpesviruses, such as herpes simplex virus-1 (HSV-1). The research aims to...
- The National Institutes of Health (NIH), through the Mental Health Research Grants program (CFDA 93.242) administered by the National Institute of Mental Health (NIMH), has awarded a $434,500 R21 grant to the University of California, San Diego (UCSD) to investigate the epigenetic mechanisms controlling HIV latency and neuropathogenesis in microglia. The project aims to use single-cell multi-omics approaches and state-of-the-art sequencing technologies to characterize the transcriptomic and...
- This $769,414 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research on how the cellular protein SAMHD1 regulates HIV-1 innate immunity and viral gene expression in primary macrophages. The long-term goal is to define the functional roles and molecular mechanisms of SAMHD1 in regulating innate immunity during persistent HIV-1 infection of macrophages. The research...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $698,390 to the Regents of the University of California at Riverside to conduct research aimed at harnessing innate immunity to control the neuroinflammatory HIV reservoir. The key objectives are to investigate how HIV infection triggers an interferon (IFN) response, how HIV overcomes this protective IFN response, and whether IFN-beta treatment can be used in conjunction with combined antiretroviral therapy to restrict HIV infection, formation of reservoirs, and neuronal injury in the brain. The research will leverage primary human cell cultures, iPSC-derived microglia, astrocytes, 2D CNS models, and a 3D CNS-on-a-chip tissue culture system to study these questions. The award has an initial period of performance from August 1, 2025 to June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $698.4k | 7/25/25 |