Project Grant R01MH139650

Award Date 5/1/25
Completion Date 2/28/30
Dollars Obligated $784K
Federal Grant Program
93.242
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This $107,948 federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to leverage ultra-high field magnetic resonance imaging (MRI) to investigate how repetitive transcranial magnetic stimulation (rTMS) alters glutamate signaling and functional connectivity in the salience network of patients with major depressive disorder. The award supports a research project being conducted by The Trustees of the...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $420,468 to validate the use of closed-loop prefrontal transcranial magnetic stimulation (TMS) in a non-human primate model. The primary goals are to: 1) identify markers of TMS engagement in the prefrontal cortex using invasive electrophysiological recordings, 2) characterize the effects of closed-loop TMS on neural responses, and 3)...
This federal Project Grant award for $830,409, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will fund the development of novel software and computational techniques to improve the accuracy of transcranial magnetic stimulation (TMS) targeting and dosimetry for individualized treatment of brain diseases. The grant recipients, Brigham & Women's Hospital Inc. and its sub-awardee Massachusetts General Hospital, will...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $182,528 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a multifocal transcranial magnetic stimulation (TMS) system combined with electroencephalography (EEG) to study network-level brain connectivity in major depressive disorder. The project aims to optimize targeting of brain subregions...
This federal Project Grant award of $968,769 from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 (Mental Health Research Grants) will fund a study to investigate the efficacy of maintenance repetitive transcranial magnetic stimulation (rTMS) treatment for individuals with treatment-resistant depression. The study will be conducted across three research sites - the University of California San Diego, Cornell University, and Australian National University. The R61 phase...
This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 Mental Health Research Grants, is funding a research study at the University of California, San Diego (UCSD) to investigate cortical inhibition as a biomarker of response for a comparison of bilateral versus unilateral accelerated theta burst stimulation (ATBS) for suicidal ideation in treatment-resistant depression. The $197,576 award, effective September 1, 2024 through August 31, 2029, will...
The National Institute of Mental Health (NIMH) awarded a $135,268 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Leland Stanford Junior University to develop novel approaches for assessing depression and anxiety symptoms among patients with cardiovascular disease or diabetes. The key objectives of this 4-year grant (8/1/2024 - 7/31/2028) are to: 1) Leverage large language model algorithms to analyze patient portal messages and identify symptomatic issues and...
The National Institute of Mental Health (NIMH) awarded a $498,000.98 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The Washington University in St. Louis to conduct research on precision functional mapping techniques to identify biomarkers for treatment-resistant depression (TRD). The research, spanning June 2024 to July 2027, aims to develop and apply novel neuroimaging methods to characterize brain network features associated with TRD and separate state from trait...
This $576,337 National Institute of Mental Health project grant funds research at Stanford University to evaluate a biomarker-guided intervention approach for anhedonia in treatment-resistant depression. The grant supports a clinical trial targeting D3 receptor agonism with pramipexole to determine its effects on ventral striatum brain activation as measured by functional neuroimaging. The study aims to enroll treatment-resistant depression patients with prominent anhedonia to evaluate whether...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants provides $638,872 to The Feinstein Institutes for Medical Research to elucidate the mechanisms by which deep brain stimulation (DBS) of the medial forebrain bundle modulates the reward network in individuals with treatment-resistant depression. The project aims to characterize the temporality of reward network changes induced by DBS using functional and...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under their Mental Health Research Grants program (CFDA 93.242), provides $784,096 to The Leland Stanford Junior University (Stanford University) to conduct research aimed at improving depression treatment by establishing reliable markers of prefrontal cortex excitability. The project aims to investigate how adjusting transcranial magnetic stimulation (TMS) parameters affects neural activity, optimize a TMS-based method called TARGET to enhance measurement of early local TMS-evoked potentials, and test how these optimized measures can detect changes in prefrontal excitability induced by cognitive tasks and repetitive TMS treatment. The research is expected to characterize the neural effects of TMS parameter adjustments and develop efficient methods for assessing cortical excitability, which could enhance brain-based monitoring and facilitate personalized treatments for depression guided by cortical excitability measurements. The award period runs from May 1, 2025 to February 28, 2030.

Generated 5/13/25, 3:38 AM