Project Grant R01EY037799
- The National Eye Institute awarded Emory University $126,530 in project grant funding on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of ezrin in Schlemm's canal cell mechanobiology in primary open-angle glaucoma. The research addresses how mechanical forces regulate transcellular pore (i-pore) formation in the Schlemm's canal inner wall, a key determinant of aqueous humor outflow and intraocular pressure. Ezrin, a mechano-responsive protein linking...
- The National Eye Institute awarded Baylor College of Medicine $100,228 on March 22, 2027, under the Vision Research program (CFDA 93.867) to validate endothelial mediators in glaucoma neurovascular dysfunction using ligandomics technology. The recipient will independently validate the binding selectivity of glaucoma-associated endothelial ligands to ocular hypertensive versus healthy retinal vessels and verify their functional roles in retinal ganglion cell loss and neurovascular dysfunction...
- The National Eye Institute awarded Tufts Medical Center Parent, Inc. $490,875 on August 1, 2026, under the Vision Research program (CFDA 93.867) to conduct genome-wide association studies on steroid-induced ocular hypertension and related glaucomas, with focus on the COL11A1 genetic locus and its role in trabecular meshwork and juxtacanalicular tissue fibrosis that impedes aqueous humor outflow. The research project examines how genomic variants in COL11A1, which encodes the alpha1 chain of type...
- The National Eye Institute awarded The Schepens Eye Research Institute $545,948 on April 1, 2026, under the Vision Research program (CFDA 93.867) to support Project Grant R01EY037230, "Understanding the Role of Reactive Astrocytes in Glaucoma." The award funds research into how astrocytes—the primary cellular component of the optic nerve head—become reactive in glaucoma and alter their support of retinal ganglion cells. The project investigates metabolic changes in astrocytes exposed...
- The National Eye Institute, part of the National Institutes of Health within the Department of Health and Human Services, awarded Creighton University $350,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support discovery and development of novel trifunctional hybrid compounds for glaucoma therapy. The funded research focuses on designing and evaluating trifunctional hybrid compounds that integrate three disease-modifying entities—an FP...
- The National Eye Institute (NEI) awarded $764,881 to the University of Colorado-Denver under the Vision Research program (CFDA 93.867) on September 15, 2025, to support a two-year research project investigating the role of advanced glycation end products (AGEs) in primary open-angle glaucoma (POAG). The project will generate fundamental research findings and preclinical data on how AGEs accumulate in trabecular meshwork (TM) tissues and contribute to elevated intraocular pressure and optic nerve...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- The National Eye Institute awarded The Johns Hopkins University $698,999 on July 1, 2026, under the Vision Research program (CFDA 93.867) to conduct research on mechanisms of functional retinal engraftment by transplanted retinal ganglion cells for optic neuropathies including glaucoma. The project addresses the death of retinal ganglion cells (RGCs), which transmit visual information from the eye to the brain. While existing treatments slow vision loss in some progressive optic neuropathies, no...
- The National Institutes of Health National Eye Institute awarded The Regents of the University of California, doing business as University of California, Berkeley, $633,742 on July 1, 2026, under the Vision Research program (CFDA 93.867) to investigate a novel lymphatic pathway for ocular aqueous humor drainage and develop therapeutic strategies for glaucoma treatment. The recipient will assess the specific role of the conjunctival lymphatic pathway in aqueous humor drainage and intraocular...
- The National Eye Institute of the Department of Health and Human Services awarded $571,206 to the University of Maryland, Baltimore on May 1, 2026, under the Vision Research program (CFDA 93.867) to develop, refine, and validate sensitive and robust adaptive optics-optical coherence tomography (AO-OCT) biomarkers for glaucoma detection and progression monitoring. The project addresses the need for earlier detection of glaucoma progression and mechanistically relevant biomarkers to support...
The National Eye Institute awarded The Trustees of Columbia University in the City of New York $532,079 on September 1, 2026, under the Vision Research program (CFDA 93.867) to characterize the role of apelin signaling in Schlemm's canal development and its relationship to early-onset glaucoma. The research employs mouse models to express and trace the apelin receptor during Schlemm's canal development, uses conditional and inducible mouse models to study loss of apelin receptor function across spatial and temporal dimensions, and applies single-cell transcriptomics to probe the underlying mechanisms of apelin signaling. The work characterizes the apelin receptor loss-of-function phenotype using ocular physiology techniques to understand its role in congenital glaucoma. The research addresses the molecular program governing Schlemm's canal endothelial cell development, which shares both vascular and lymphatic traits and regulates aqueous humor outflow and intraocular pressure—a major risk factor for glaucoma. Work is performed in New York, NY with a period of performance from September 1, 2026, through July 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $532.1k | 8/25/26 |