Project Grant R56DE036400
- The National Institute of Dental and Craniofacial Research awarded The Regents of the University of Colorado (University of Colorado-Denver) $552,009 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop autologous organoid and humanized mouse models with thymic T cell education capacity for testing head and neck cancer immunotherapy. The award funds development of stem cell-derived thymic organoids (STOs) and isogenic multicellular models generated...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- The National Institute of Dental and Craniofacial Research awarded The University of Texas MD Anderson Cancer Center $1,470,872 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to elucidate subclonal evolution and fitness dynamics in oral carcinogenesis. The research identifies and interrogates the functional importance of genomic events that drive subclonal selection as oral premalignant lesions (OPL) transform into oral squamous cell carcinoma (OSCC)....
- The National Institute of Dental and Craniofacial Research awarded The Regents Of The University Of Colorado (University of Colorado-Denver) $513,174 under the Project Grant R01DE035831 on May 1, 2026, through the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research on platelet-derived growth factor receptor (PDGFR) dimer-specific dynamics in craniofacial mesenchyme development. The project investigates how differential internalization and trafficking of various...
- The National Institute of Dental and Craniofacial Research awarded $597,769 to the Trustees of Columbia University in the City of New York on August 3, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, a Project Grant). The award funds development of an engineered hydrogel-patient-derived organoid platform with tunable viscoelastic properties designed to model oral epithelial dysplasia and recapitulate the biomechanics of dysplasia and oral squamous cell carcinoma...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Minnesota $1.947 million on June 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate how the pioneer oral bacterium Streptococcus gordonii recognizes and responds to other early dental plaque colonizers and host factors, shaping initial biofilm community structure. The research examines the outside-in signaling circuit through which S. gordonii...
- The National Institute of Dental and Craniofacial Research, part of the National Institutes of Health under the Department of Health and Human Services, awarded The University of Chicago $328,000 on August 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a microsimulation model of oral health lifetime outcomes and resource use in older adults. The project, titled "Development and Validation of the U.S. Oral Health Microsimulation...
- The National Institute of Dental and Craniofacial Research awarded the University of North Carolina at Chapel Hill $682,398 under the Oral Diseases and Disorders Research program (CFDA 93.121) on August 1, 2026. The recipient will develop a predictive algorithm to identify individuals at high risk of developing long COVID based on high-resolution phenotyping of the immunologic, microbial, proteomic, and metabolomic landscape of the oral cavity during and after SARS-CoV-2 infection. The project...
- The National Institute of Dental and Craniofacial Research awarded the University of Pennsylvania $427,839 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a multimodal imaging platform integrating stimulated Raman scattering (SRS) microscopy with tissue immunofluorescence for spatially resolved metabolic mapping at single-cell resolution in human papillomavirus-positive head and neck squamous cell carcinoma tissue. The research...
- This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
The National Institute of Dental and Craniofacial Research awarded The Regents of the University of Colorado, doing business as University of Colorado-Denver, $656,545 in project grant funding on August 24, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research to characterize the spatial and functional architecture of recurrent oral squamous cell carcinoma by integrating immune cell distribution with bacterial localization, transcriptomics, and bacterial meta-transcriptomics. The funded research aims to develop a predictive biomarker panel combining multi-omics data (transcriptomics, proteomics, bacterial genomics) with machine learning to predict recurrence-free survival, and to validate this panel in a prospective, multi-institutional oral squamous cell carcinoma cohort in both surgical and pretreatment biopsy specimens. The research addresses the critical unmet need for accurate prognostic tools in oral squamous cell carcinoma by integrating spatial multi-omics and microbiome profiling to generate a clinically applicable risk stratification tool. Performance occurs in Aurora, Colorado, with an award period of August 24, 2026 through August 23, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $656.5k | 8/25/26 |