Project Grant R21DE036022
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- The National Institute of Dental and Craniofacial Research awarded the University of Pittsburgh $1.899 million on September 19, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to analyze high-dimensional genomic datasets of head and neck squamous cell carcinomas and reveal mechanistic insights on divergent clinical outcomes between HPV-positive and HPV-negative tumors using systems biology modeling coupled with experimental validation. The project will employ novel...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded The Washington University $427,625 on February 6, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research to develop and evaluate radiation-guided theranostic agents for detecting and monitoring response to oral cancer treatment. The research leverages radiation-inducible antigens, specifically...
- The National Institute of Dental and Craniofacial Research awarded the University of Pennsylvania $249,000 on February 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to establish an independent laboratory investigating the role of Selenomonas sputigena in early childhood caries biofilm formation. The project will characterize how S. sputigena, a motile oral bacterium associated with early childhood caries, colonizes tooth surfaces and organizes with Streptococcus...
- The National Institute of Dental and Craniofacial Research awarded Virginia Commonwealth University $632,383 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct mechanistic research on phosphatidylinositol 4-phosphate 5-kinase I5 (PIPKIGI5) in head and neck squamous cell carcinoma immunotherapy. The funded research explores how PIPKIGI5, an endosome-localized lipid kinase, regulates interferon-gamma signaling and tumor immunogenicity in head...
- The National Institutes of Health National Institute of Dental and Craniofacial Research awarded The Trustees Of The University Of Pennsylvania $521,273 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds research into dendritic cell and T cell dysregulation in periodontitis associated with poorly controlled diabetes. The project examines how hyperglycemia reprograms dendritic cells and T cells through epigenetic mechanisms, activating...
- The National Institute of Dental and Craniofacial Research awarded $528,460 to the University of Pennsylvania on July 2, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop single-scan multi-contrast cranial MRI technology for pediatric patients with congenital birth defects. The funded work addresses the clinical need to reduce ionizing radiation exposure in children evaluated for craniofacial skeletal pathologies such as craniosynostosis, a condition affecting...
- The National Institute of Dental and Craniofacial Research awarded The Trustees of The University of Pennsylvania $522,405 on May 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of taste receptor cells in periodontal homeostasis. The research focuses on how solitary chemosensory cells and macrophages in gingival tissue protect against periodontal disease through taste-like signaling pathways. The work addresses the mechanisms by which these...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Michigan $652,280 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to advance understanding of HPV integration events in oropharyngeal squamous cell carcinoma (OPSCC). The funded research develops novel sequencing and informatics approaches to characterize how human papillomavirus integrates into tumor genomes in HPV-positive OPSCC patients. The work...
- The National Institute of Dental and Craniofacial Research awarded Virginia Commonwealth University $181,736 on December 1, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct research on therapy-induced senescence as a therapeutic target in head and neck squamous cell carcinoma. The research investigates the cGAS-STING pathway as a mechanism regulating therapy-induced senescence—a dormant yet metabolically active cellular state that may contribute to tumor cell...
The National Institute of Dental and Craniofacial Research awarded the University of Pennsylvania $427,839 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop and validate a multimodal imaging platform integrating stimulated Raman scattering (SRS) microscopy with tissue immunofluorescence for spatially resolved metabolic mapping at single-cell resolution in human papillomavirus-positive head and neck squamous cell carcinoma tissue. The research addresses a critical gap in current biomedical imaging: the inability to simultaneously map metabolic states of individual cells while preserving patient tissue architecture. The project will establish an integrated imaging workflow combining SRS microscopy, deuterium-labeled metabolic tracers, and immunofluorescence staining in patient-derived organotypic tumor slice culture to understand how spatial metabolic heterogeneity within the tumor microenvironment influences treatment response in HPV+ head and neck cancer. Work is performed in Philadelphia, Pennsylvania, with a period of performance from August 1, 2026, through July 31, 2028. This is a project grant, the standard NIH investigator-initiated research mechanism under the Oral Diseases and Disorders Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.8k | 7/28/26 |