This federal Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a revolutionary DNA sequencing platform by Xgenomes Corp. The $384,418 award, active from September 2024 to May 2025, aims to construct a proof-of-concept for a super-resolution, single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides. The proposed approach uses advanced statistical and...
The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...
This Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) provides $215,088 to Directseq Biosciences, Inc. to develop and test an "Exhaustive De Novo Sequencing of Every RNA in a Sample by a Layer-by-Layer Mass Spectrometry Ladder Intensity Approach." The project aims to create a comprehensive RNA sequencing and modification profiling method that can identify and sequence all RNA species in a sample...
This Project Grant award from the National Institutes of Health's National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $406,500 to Directseq Biosciences, Inc. to advance their next-generation mass spectrometry-based sequencing (NGMS-SEQ) methods for high-throughput direct sequencing and quantitative mapping of RNA modifications. The key objectives are to: 1) enhance NGMS-SEQ techniques to enable direct sequencing of various tRNA samples, including...
The National Institute of Standards and Technology (NIST) awarded a $955,000 Project Grant under the Congressionally-Identified Projects program (CFDA 11.617) to HMH Hospitals Corporation in Edison, NJ. The grant establishes a nanopore long-read DNA sequencing capability as a core facility within the HMH Center for Discovery and Innovation. Specific equipment and technologies to be procured include the PromethION high-throughput and GridION medium-throughput sequencing systems, along with...
The National Human Genome Research Institute (NHGRI) has awarded Atlasxomics Inc. a $799,858 Project Grant (CFDA 93.172 - Human Genome Research) to develop a next-generation, user-friendly spatial epigenomics chip that is adaptable to automation workflows. The key objectives of this Phase I SBIR study are to: Improve the ease of use and flexibility of Atlasxomics' existing spatial epigenomics platform, the Deterministic Barcoding in Tissue for Spatial Omics Sequencing (DBiT-seq) system, to...
The National Human Genome Research Institute (NHGRI) awarded a $1,247,028 Project Grant under the Human Genome Research CFDA program (93.172) to Cantata Bio LLC, a small business located in Santa Cruz, California. The grant supports the development and commercialization of Cantata Bio's innovative "VariLink" Hi-C platform, which is designed to enhance the detection of genetic variants, including large structural variants and smaller mutations, in cancer research. The VariLink...
Sequegenics LLC received a $251,073 Project Grant award from the National Science Foundation Division of Industrial Innovation under the Engineering federal grant program (CFDA 47.041). The grant supports development of low-cost and scalable methods for creating genomic databases using long-read next-generation DNA sequencing technologies. This aligns with the program's goals of fostering innovation in engineering research. The one-year project period runs from August 1, 2021 through July 31,...
This National Science Foundation (NSF) Cooperative Agreement award, funded under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084), provides $1,250,000 to Micropure Genomics Inc., a minority-owned small business, to develop an innovative automated platform for preparing high-quality DNA samples for long-read sequencing applications. The project aims to address critical barriers in genomic sequencing by advancing a novel technology for DNA sample preparation. Key...
This Project Grant award from the National Institutes of Health's National Human Genome Research Institute provided $768,678 to Molecular Assemblies, Inc. to develop a fully enzymatic oligonucleotide synthesis cycle using engineered template-independent polymerases and a novel phosphate dNTP blocking group. The award supports the goals of the Human Genome Research program (CFDA 93.172) to accelerate genome research and its application to human health. Specifically, the awardee will engineer...