Project Grant R43HG011608

Award Date 3/17/21
Completion Date 2/28/22
Dollars Obligated $1M
Federal Grant Program
93.172
Assistance Type
Project Grant
Place of Performance
New Mexico, USA
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This federal Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports the development of a revolutionary DNA sequencing platform by Xgenomes Corp. The $384,418 award, active from September 2024 to May 2025, aims to construct a proof-of-concept for a super-resolution, single-molecule sequencing technology that can read short sequence "words" rather than individual nucleotides. The proposed approach uses advanced statistical and...
The National Human Genome Research Institute (NHGRI), under the Federal Grant Program "Human Genome Research" (CFDA 93.172), awarded a $407,291 Phase I Small Business Innovation Research (SBIR) grant to Electronic Biosciences, Inc. to develop a nanopore-based protein sequencing platform. The project aims to create a high-accuracy, label-free nanopore reader capable of direct, single-molecule protein sequencing. This novel technology would enable proteome-wide profiling, biomarker...
This Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172) provides $215,088 to Directseq Biosciences, Inc. to develop and test an "Exhaustive De Novo Sequencing of Every RNA in a Sample by a Layer-by-Layer Mass Spectrometry Ladder Intensity Approach." The project aims to create a comprehensive RNA sequencing and modification profiling method that can identify and sequence all RNA species in a sample...
This Project Grant award from the National Institutes of Health's National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) provides $406,500 to Directseq Biosciences, Inc. to advance their next-generation mass spectrometry-based sequencing (NGMS-SEQ) methods for high-throughput direct sequencing and quantitative mapping of RNA modifications. The key objectives are to: 1) enhance NGMS-SEQ techniques to enable direct sequencing of various tRNA samples, including...
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Armonica Technologies, Inc. was awarded a $1,047,600 Project Grant from the National Human Genome Research Institute of the Department of Health and Human Services to develop a novel DNA sequencing platform. The award was made under the Human Genome Research program (CFDA 93.172), which supports technologies to accelerate genomic research and its application to human health.

Specifically, Armonica will use the funding to optimize a metal-insulator-metal structure for single base sensitivity and spatial localization in Raman scattering readout. The company aims to demonstrate single base sensitivity to sequence DNA without labels in a coupled nanopore-nanochannel system. DNA would be partially stretched in nanochannels and forced through tortuous nanopores in the roof, with an electromagnetic field enhancement allowing detection of individual bases via surface-enhanced coherent anti-Stokes Raman scattering as they pass through. The platform could potentially provide high-throughput, accurate long-read sequencing in a massively parallel and cost-effective manner.

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