Project Grant R41AA031429
Award Date
9/20/24
Completion Date
8/31/25
Dollars Obligated
$399K
Federal Agency
National Institute on Alcohol Abuse and Alcoholism
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
Utah, USA
Similar Awards
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under CFDA 93.273 - Alcohol Research Programs provides $499,987.00 to CFD Research Corporation to develop a High Throughput Alcohol Screening Platform (HT-ASP) that incorporates cortical organoids. The goal is to create an automated system capable of maturing, maintaining, and assaying over 100 organoids in culture to provide a robust and genetically diverse platform for screening potential alcohol use...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $131,654 to Biomedit LLC to develop a Lactobacillus-vectored alkaline phosphatase (AP) delivery system to mitigate alcohol-induced leaky gut and endotoxin load. The key goals of this 2-year project are to: 1) Generate engineered live biotherapeutics (ELBPs) that can effectively deliver the proprietary AP enzyme (INPRO) developed by...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $235,750 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Rhode Island Hospital to study the detection and monitoring of alcohol-related white matter brain pathology. The project aims to leverage the hospital's existing bank of human alcohol use disorder (AUD) and control serum samples to characterize the effects of ethanol and different treatments on the expression of oligodendrocyte/myelin proteins,...
This federal Project Grant award, valued at $523,477.00 and awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) on September 25, 2024, supports research to study alcohol-associated liver disease (ALD) and its interaction with the rs738409 variant in the PNPLA3 gene. The key products and services to be delivered under this grant include: Developing a human induced pluripotent stem cell (hiPSC)-derived in vitro liver culture...
This $673,500 Project Grant from the National Institutes of Health's National Institute on Alcohol Abuse and Alcoholism will fund Amygdala Neurosciences, Inc. to develop new, potent, selective, and reversible inhibitors of aldehyde dehydrogenase 2 (ALDH2) for the treatment of alcohol use disorder. The goal is to implement an innovative screening technology to discover novel compounds that reduce craving and alcohol consumption by selectively inhibiting ALDH2 in a reversible manner, avoiding...
This Cooperative Agreement award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $999,393 to Stress Therapeutics, Inc. to initiate investigational new drug (IND)-enabling studies for a novel first-in-class therapeutic candidate aimed at the chronic management of pathological hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis for the treatment of alcohol use disorder (AUD). The key activities funded under...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support research to examine the potential utility and risks of non-alcoholic beverages in reducing alcohol consumption. The award, totaling $178,805, will fund a study led by Dr. Bowdring at The Leland Stanford Junior University (Stanford University) to use ecological momentary assessments (EMA) to assess the relationship...
This $317,534.10 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to understand the metabolic disruptions that lead to fetal growth deficits in prenatal alcohol exposure (PAE). The researchers at the University of North Carolina at Chapel Hill will quantify how alcohol alters maternal-fetal glucose and insulin signaling, with the goal of identifying the underlying mechanisms that...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, provides $613,777 to The Pennsylvania State University to conduct a prospective examination of transdermal alcohol concentration (TAC) features as predictors of alcohol-related consequences and alcohol use disorders (AUD) among young adults. The research will use a large-scale measurement burst design consisting of eight...