Project Grant R21AA032106

Award Date 9/25/24
Completion Date 8/31/26
Dollars Obligated $236K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
Providence, RI 02903, USA
Similar Awards
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development of novel 3D human brain circuits to investigate the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award to the University of North Carolina at Chapel Hill will fund research to elucidate how alcohol-induced changes in microglial metabolism...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $151,869 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Iowa. The grant, awarded on May 1, 2025, supports research to understand the impact of chronic alcohol exposure on metabolic function and tau pathology in Alzheimer's disease (AD) progression. The key objectives of the project are to: 1) assess the influence of chronic ethanol exposure on metabolic function and tau pathology in the...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $537,587 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Texas Southwestern Medical Center to conduct research on the metabolic consequences of liver inflammation on alcohol consumption and alcohol-associated liver disease (ALD). The key objectives are to identify the mechanisms by which the transcription factor IRF3 suppresses the expression and secretion of the metabolic regulator...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $328,500 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center-Shreveport to investigate the role of lysophosphatidic acid (LPA) signaling in alcohol-induced blood-brain barrier (BBB) disruption and neuroinflammation. The research aims to assess the effects of heavy alcohol consumption on mitochondrial function, redox balance, and the ability of LPP3 (a regulator of the...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...
This federal Project Grant award, totaling $517,248.00, was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program. The award supports research to explore the mechanisms by which acute and chronic alcohol exposure regulate a norepinephrine-astrocyte-dopamine arousal pathway in the ventral periaqueductal gray (VPAG) region of the brain, and how this pathway contributes to alcohol-related changes in sleep behavior....
This Project Grant award of $594,784 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a postmortem, multi-omic study of brains from 341 total subjects to identify novel lasting transcriptomic and epigenetic changes in biological pathways that may serve as biomarkers and therapeutic targets for alcohol use disorder (AUD). The research will analyze RNA sequencing and whole-genome bisulfite sequencing data across 8 brain...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $220,656 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center (UNMC) division. The grant will fund research to investigate the effects of ethanol metabolism on the sorting of non-isgylated HIV proteins to hepatocyte-derived exosomes, and how these exosomes impact the pro-fibrotic activation of hepatic stellate...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has awarded a $152,000 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Des Moines University Osteopathic Medical Center (DMU) to study the role of GLUD1 receptors in regulating structural plasticity during chronic ethanol exposure and withdrawal. The two-year grant, awarded on September 1, 2023, will support DMU's research aimed at understanding how GLUD1 receptor function and expression influence dendritic spine...
This $1,373,036 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support a research project to enhance understanding and prediction of heavy drinking episodes during initial recovery from alcohol use disorder (AUD). The project aims to leverage wearable biosensors and artificial intelligence to develop real-time predictive models that can forecast high-risk drinking periods and identify the...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $235,750 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Rhode Island Hospital to study the detection and monitoring of alcohol-related white matter brain pathology. The project aims to leverage the hospital's existing bank of human alcohol use disorder (AUD) and control serum samples to characterize the effects of ethanol and different treatments on the expression of oligodendrocyte/myelin proteins, sphingolipids, and indices of stress in extracellular vesicles (EVs) isolated from serum. The research will assess the sensitivity and specificity of analyzing total versus oligodendrocyte-derived (O4+) EVs to detect white matter alcohol-related brain degeneration (ARBD) effects and responses to treatment. The grant has an award date of September 25, 2024, and an ultimate completion date of August 31, 2026.

Generated 7/1/25, 4:48 AM