Project Grant R01AA031226

Award Date 9/25/24
Completion Date 6/30/29
Dollars Obligated $523K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
Cleveland, OH 44195, USA
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This federal Project Grant award, valued at $523,477.00 and awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) on September 25, 2024, supports research to study alcohol-associated liver disease (ALD) and its interaction with the rs738409 variant in the PNPLA3 gene.

The key products and services to be delivered under this grant include:

  • Developing a human induced pluripotent stem cell (hiPSC)-derived in vitro liver culture system to model ALD pathogenesis and investigate the role of macrophage-induced hepatocyte dedifferentiation (Aim 1)
  • Examining the impact of alcohol exposure on specific gene expression and signaling pathways that contribute to the heightened sensitivity of hepatic stellate cells to lipopolysaccharide and TGF-beta (Aim 2)
  • Unraveling the role of the rs738409 genetic variant in PNPLA3 in the development of ALD (Aim 3)

This research aims to enhance diagnostic capabilities and advance effective therapeutic interventions for ALD, a growing public health problem with significant global impact but limited treatment options.

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