The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, awarded a $499,987 Project Grant to CFD Research Corporation. The grant funding will support the development of a High Throughput Alcohol Screening Platform (HT-ASP) that incorporates cortical organoids, which are advanced 3D tissue models representing the human brain. This system will automate the maturation, maintenance, and assaying of over 100 brain organoids simultaneously to enable high-throughput screening of potential therapeutic candidates for treating alcohol use disorder (AUD). The project aims to create a robust and genetically diverse platform for evaluating drug candidates, leveraging the unique capabilities of cortical organoids to model the specific effects of alcohol on the prefrontal cortex, which is a key brain region involved in AUD.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $500.0k | 5/15/25 |