The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $581,869 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Kentucky Research Foundation. The grant will fund a rigorous 4-year crossover study to translate preclinical findings on the role of glucocorticoid receptors in alcohol use disorder (AUD) to humans. The study will use the selective glucocorticoid receptor antagonist PT150 to examine its effects on stress-induced and alcohol-induced...
This federal Project Grant award of $701,135 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will fund research to characterize brain-periphery cortisol dysregulation in alcohol use disorder (AUD). The research will use a novel radiotracer and PET brain imaging to measure the availability of the cortisol-regenerating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in the brains of...
This $673,500 Project Grant from the National Institutes of Health's National Institute on Alcohol Abuse and Alcoholism will fund Amygdala Neurosciences, Inc. to develop new, potent, selective, and reversible inhibitors of aldehyde dehydrogenase 2 (ALDH2) for the treatment of alcohol use disorder. The goal is to implement an innovative screening technology to discover novel compounds that reduce craving and alcohol consumption by selectively inhibiting ALDH2 in a reversible manner, avoiding...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, awarded a $499,987 Project Grant to CFD Research Corporation. The grant funding will support the development of a High Throughput Alcohol Screening Platform (HT-ASP) that incorporates cortical organoids, which are advanced 3D tissue models representing the human brain. This system will automate the maturation, maintenance, and assaying of over 100 brain...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $275,171.12 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of California, Los Angeles (UCLA) on July 24, 2024. The grant will support a clinical neuroscience study to understand stress coping mechanisms in individuals with Alcohol Use Disorder (AUD) compared to matched controls. The research aims to objectively assess chronic stress and examine dynamic functional connectivity within the...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) to Yale University for $366,406.00 will support the development of a novel human laboratory paradigm to screen alcohol use disorder (AUD) medications. The project aims to create two models that can assess an individual's ability to resist drinking and measure heavy drinking behavior, mapping to key FDA endpoints for AUD medication approval and WHO risk...
Under a $368,673 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded on September 25, 2023, Artiam Bio Inc., a minority-owned small disadvantaged biotechnology company, is developing and evaluating second-generation partial inverse agonists targeting the type 1 cannabinoid (CB1) receptor as a potential therapy for alcohol use disorder (AUD). Artiam Bio is conducting preclinical efficacy studies of its lead CB1 receptor partial inverse agonist compound in rat...
This $498,121.57 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), will support research to investigate the neural mechanisms that drive maladaptive coping strategies and subsequent alcohol use following exposure to stress. The principal investigator will utilize an animal model to study how dysfunction in the corticolimbic circuitry, specifically the prelimbic cortex and basolateral amygdala, contributes...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $545,282 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Colorado-Denver to study neural mechanisms associated with emotion regulation and alcohol cue reactivity during early abstinence from alcohol use disorder (AUD). The 5-year project aims to determine how neural function related to cognitive reappraisal and alcohol cue processing changes across early AUD treatment, and whether...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, provides $385,000 to Soovu Labs Inc. to develop a novel wearable medical device for treating stress and anxiety in individuals with alcohol use disorder (AUD). The award aims to determine optimal stimulation parameters for activating C-tactile fibers and TRPV-1 channels in the peripheral nervous system, which can trigger the...