Project Grant R00AA028291

Award Date 8/15/24
Completion Date 7/31/27
Dollars Obligated $318K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
Chapel Hill, NC 27599, USA
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The key products and services to be delivered include:

  • Quantifying maternal-fetal glucose levels, gluconeogenesis, and related metabolite pools to understand how alcohol alters maternal-fetal energetics and reduces fetal glucose availability
  • Assessing insulin signaling, glucose storage, and utilization in maternal liver to determine if alcohol prevents maternal adaptation to an insulin-resistant state
  • Identifying the underlying mechanisms that mediate the failure of alcohol-exposed dams to adapt to insulin resistance, focusing on factors like leptin resistance and placental hormone activity

This research aims to provide novel mechanistic insights into the basis for fetal growth deficits associated with fetal alcohol spectrum disorders, which could inform the development of metabolite or hormone-based diagnostic tests and nutritional interventions to improve gestational outcomes.

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