Project Grant R21AA031173

Award Date 9/11/23
Completion Date 8/31/25
Dollars Obligated $438K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This federal Project Grant award in the amount of $523,477.00 was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program. The award supports a research project focused on studying alcohol-associated liver disease (ALD) and its interaction with the rs738409 variant in the PNPLA3 gene using a human induced pluripotent stem cell (hiPSC)-derived liver culture model. The key objectives are to: 1) investigate the role of...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to examine the role of non-parenchymal cells in driving the key features of alcohol-associated hepatitis (AAH) in a fully humanized mouse liver model. The $688,199 award to Yale University will fund a 5-year research project (June 1, 2025 - February 28, 2030) that aims to investigate the species-specific paracrine...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $119,600 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) with a performance period from July 2024 to July 2027. The grant funds research to identify and understand the mechanisms by which aging and alcohol consumption cooperatively contribute to the development of alcohol-associated liver disease (ALD). The project aims to...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund research to define the contributions of the MIF-CD74 signaling pathway in alcohol-associated liver disease (ALD). The $442,898 grant, awarded on September 1, 2024, will support a 5-year research plan at the University of Texas Health Science Center at Houston to: 1) characterize the role of CD74 expression in hepatocytes and myeloid...
The University of Colorado-Denver has been awarded a $179,154 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program. The funding will support research to elucidate the role of Wnt ligands and related signaling pathways in driving the activation of hepatic stellate cells, which are key mediators of liver fibrosis in alcohol-related liver disease. The 2-year project aims to characterize the impact of...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $499,987 Project Grant (CFDA 93.273 - Alcohol Research Programs) to CFD Research Corporation, a small for-profit engineering and technology firm based in Huntsville, Alabama. The grant will be used to develop a High Throughput Alcohol Screening Platform (HT-ASP) that incorporates vascularized cortical organoids as a living biological sensor platform. The goal is to create a highly robust and genetically diverse platform for...
This $1,547,718 federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund research to investigate the role of histone demethylases KDM5B and KDM5C in alcohol-associated liver disease development and resolution. The research, conducted by the University of Kansas Medical Center Research Institute, Inc. (KUMCRI), aims to determine how these epigenetic regulators in hepatocytes influence cell-cell...
The federal Project Grant award R01AA031670, sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the role of hepatic stellate cells (HSCs) in the progression of alcohol-associated hepatitis (AH). The primary awardee, the University of Southern California (USC), will conduct studies to determine how the transcription factors CYP1B1, PRRX1, and NR4A2 regulate the development of a specific...
This $214,385 Project Grant, awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development and characterization of a novel in vivo model called CHIMERA-BONCAT. This model will enable comprehensive, unbiased, and cell-type-specific proteomic analysis of the human microglial response to alcohol exposure in an in vivo environment. The research aims to: 1) Characterize the reactivity...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the CFDA 93.273 Alcohol Research Programs, provides funding to The Administrators of Tulane Educational Fund (Tulane University) to investigate the role of the TET1 enzyme and sex differences in alcohol-associated liver disease and hepatocellular carcinoma development. The $477,626 award, which runs from May 2, 2025, to April 30, 2030, aims to determine the impact of female sex and reduced...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic changes in hepatic stellate cells and senescent changes in endothelial cells to the development of severe ALD in cirrhotic livers. The proposed research will provide new insights into the mechanisms underlying ALD progression and demonstrate the utility of the liver-on-a-chip system as an in vitro platform for studying human-relevant ALD conditions.

Generated 7/16/24, 10:54 AM