This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $577,280.00 in funding to Northwestern University to support research on the signaling and metabolic regulation of nucleotide metabolism and cell growth. The research aims to uncover fundamental insights into the molecular mechanisms governing metabolic pathways that enable cellular growth and proliferation, with a focus on delineating the regulation of de novo purine synthesis, the effects of mTORC1 signaling on the methionine cycle and RNA methylation, and the role of environmental bicarbonate in fueling nucleotide synthesis. This award, with a period of performance from August 1, 2025, to May 31, 2030, will empower the researchers to pursue ambitious science and higher-risk endeavors to expand the understanding of signaling, cellular metabolism, and innovations in these areas.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $577.3k | 7/10/25 |