Project Grant R35GM152167

Award Date 8/8/24
Completion Date 6/30/29
Dollars Obligated $1.7M
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
New Haven, CT 06510, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research at Northwestern University on how RNA modifications regulate translation initiation and cellular stress responses. The $440,000 award, effective August 1, 2025 through May 31, 2030, will integrate biochemistry, chemical biology, transcriptomics, and cell biology approaches to investigate how the epitranscriptome...
The National Institute of General Medical Sciences (NIGMS) awarded a $274,597 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The 5-year grant, effective August 1, 2025, supports research on proteomic and phosphoproteomic remodeling under genomic imbalance, or aneuploidy. The project aims to study the mechanisms of protein regulation and signaling pathways in aneuploid cells, with a focus on distinguishing the effects of chromosome gain...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $812,500 in funding to The Trustees of the University of Pennsylvania (UPenn) to conduct research on RNA regulation and noncanonical translation between cell states. The research aims to map post-transcriptional regulation and the unannotated proteome, including RNA localization and modifications, to better understand how...
This federal Project Grant award for $404,792, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of telomere biology. The funded project at Yale University aims to yield new mechanistic insights into how telomeres are protected, maintained, and replicated, with potential implications for treating human diseases like cancer and aging. Key focus areas...
This National Science Foundation (NSF) Biological Sciences program grant to Yale University, totaling $940,000 over 3 years beginning March 1, 2024, aims to systematically identify features of human and viral messenger RNAs (mRNAs) that regulate protein production. The project will employ a massively parallel reporter assay to quantify the impact of RNA modifications, structured RNA elements, and cell-specific factors on mRNA translation. Insights gained will provide a comprehensive...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under its Biomedical Research and Research Training program (CFDA 93.859), supports research to understand how cells regulate protein synthesis in response to environmental stressors. The $372,880 award, with a period of performance from May 1, 2025 to April 30, 2030, will fund research by The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. to investigate three...
This Project Grant award for $466,125.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training federal grant program (CFDA 93.859). The award supports a research project at New York University School of Medicine to identify and characterize key metabolic control mechanisms, with a focus on understanding cellular mechanisms for sensing pyrimidine levels and iron availability. The project will develop cell and mouse models to...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $1,301,595.00 in funding to Yale University to conduct research on a class of recently discovered human genes called internal open reading frames (iorfs). The project aims to: 1) use long-read sequencing to identify and validate the existence of iorf-encoding alternative transcripts in human cells, 2) provide...
The National Institute of General Medical Sciences (NIGMS) awarded a $440,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York. The 5-year grant, awarded on February 3, 2025, supports advanced research to decode the ubiquitin and autophagy signaling networks, which are essential cellular processes involved in proteome homeostasis. The research program combines expertise in quantitative mass spectrometry,...
This Project Grant award, valued at $222,708.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award, which runs from May 20, 2025 to December 31, 2027, will support research at the University of California, Davis to identify the core organizational principles within nuclear mRNAs. Specifically, the project aims to use RNA structure probing and fractionation/isolation methods to...

This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Federal Grant Program (CFDA 93.859), supports research into the post-transcriptional control of gene expression by the mTORC1 signaling pathway. The $1,675,000 award to Yale University, spanning August 2024 to June 2029, will fund research to understand the molecular mechanisms that regulate mRNA translation and stability in response to nutrient signals, and how these processes specialize gene expression across different tissues. The research aims to yield insights into basic principles of gene regulation that allow cells and organisms to adapt to changing nutrient availability. This award builds on the principal investigator's prior work examining the central role of the mTORC1 pathway in controlling cap-dependent translation and the expression of growth-related genes.

Generated 8/5/25, 4:14 AM