The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant (CFDA 93.859 Biomedical Research and Research Training) to The Johns Hopkins University totaling $387,500.00 with an award date of January 3, 2025 and an ultimate completion date of December 31, 2029. This research project will focus on determining the molecular mechanisms that regulate the activity of protein kinases, which are integral to human health and play a key role in numerous signaling pathways...
This $409,375 Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) to The Johns Hopkins University. The grant will fund research to uncover the mechanisms of how ligand-gated ion channels (LGICs), specifically AMPA receptors, function and are regulated at the molecular and structural level. The research will utilize time-resolved cryo-electron microscopy and other biophysical...
The National Institute of General Medical Sciences (NIGMS) awarded a $385,000 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Rochester. The grant, which runs from August 1, 2024 to June 30, 2029, will support research to develop new noncovalent motifs and reactions to interface with and intervene in biological processes. Specifically, the research aims to create supramolecular mimics of natural chaperones to modulate protein folding...
The National Institute of General Medical Sciences (NIGMS) awarded a $363,392 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to The Johns Hopkins University. The grant, awarded on January 1, 2025, will fund the development of computational methods to characterize alternative splicing and genetic determinants from heterogeneous sequence data. The project aims to create a general framework and specialized tools to detect and model alternative splicing variation from...
This federal Project Grant award in the amount of $479,487.00 was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support research to examine how physical cues such as extracellular fluid viscosity, microenvironmental stiffness, and confinement impact cell function and behavior, particularly related to cell migration processes. The research aims to develop a comprehensive understanding...
The National Institute of General Medical Sciences (NIGMS) awarded a $984,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to support research focused on "Expanding Access to Molecular Complexity through Natural Product Synthesis." The project aims to develop new tools and strategies for the synthesis of complex natural products, which can serve as vital medicines and advance the field of organic...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,637,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Johns Hopkins University to investigate the mechanisms that control DNA repair pathway choice. The research aims to understand how dynamic changes in chromatin and nuclear RNAs regulate genome maintenance across different cell states and physiological contexts. The project combines genomics approaches, mouse genetics, and innovative...
This federal Project Grant award for $387,500.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to understand the roles of microRNAs in animal development. The long-term goal of this research program is to elucidate the gene regulatory mechanisms that enable a single-celled zygote to develop into a multicellular organism. Specifically, the project focuses on studying the...
This $240,000 project grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a "plug-and-play platform for the continuous directed evolution of nonribosomal peptide synthetases (NRPS)." The goal is to create a live-cell reporter system to rapidly evolve NRPS enzymes with designer substrate specificities. This will enable the programming of these natural product assembly lines to produce...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $584,420.00 to the Albert Einstein College of Medicine to investigate the role of protein motions associated with intrinsic disorder and their specific functions. The project aims to gain a deeper understanding of the nuclear pore complex and how flexible proteins facilitate the transport of biomolecules in and out of the...