Project Grant R35GM155002

Award Date 9/1/24
Completion Date 8/31/29
Dollars Obligated $389K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Piscataway, NJ 08854, USA
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This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are:

  1. Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes.

  2. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable mimics of RNA-cleaving ribozymes, as well as cyclic (thio)phosphoramidate dinucleotides as biostable agonists of the cGAS-STING pathway for inflammation.

  3. Enhancing the therapeutic potential of nucleic acid catalysts (NAzymes) by introducing programmable RNA cleavage functionality that can be selectively activated under disease conditions.

This research aims to advance the field of nucleic acid therapy and drug development for precision medicine, while also promoting diversity and inclusivity through cross-institutional collaborations and professional development opportunities. The award period runs from September 1, 2024 to August 31, 2029.

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