The National Institute of General Medical Sciences (NIGMS) awarded a $925,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The grant supports a multidisciplinary research program to discover chemical modulators of RNA-protein assemblies, with a focus on targeting Dead-box RNA-dependent ATPases. The project aims to identify allosteric compounds that stabilize Dead-box protein-RNA interactions, optimize...
This Project Grant award, valued at $372,210.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support research at San Diego State University Foundation to develop synthetically modified, fluorescent nucleosides and oligonucleotides. The goals of this research program are to: (1) create fluorescent probes to image the uptake and endosomal escape of therapeutic...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is funding research by the Massachusetts Institute of Technology (MIT) to develop new chemical reagents and methods for synthesizing oligophosphate constructs. The goal is to create tools for studying the roles of phosphorylated biomolecules, including nucleosides, lipids, amino acids, peptides, and proteins, in human physiology,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $379,131 to the University of North Carolina at Chapel Hill to conduct research aimed at accelerating the development of macromolecule-based therapeutics. The key objectives are to: 1) establish rapid characterization assays to assess the conformation and dynamics of disordered peptides and peptidomimetics, 2)...
The National Institute of General Medical Sciences (NIGMS) awarded a $470,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Institute For Cancer Research, a non-profit subsidiary of Temple University, for a 5-year research project starting on September 17, 2024. The goal of the project is to characterize the molecular-level interactions and coordination events coupling the repair of oxidative DNA damage and gene enhancement at G-quadruplex promoter regions in...
The National Institute of General Medical Sciences (NIGMS) awarded a $305,892 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Dotquant LLC, a biotechnology research and development company, to develop a new in vitro transcription kit for high-yield synthesis of chemically modified RNA. The project aims to combine the benefits of wild-type T7 RNA polymerase, which has high efficiency and low cost, with the ability of mutant T7 RNA polymerases to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is funding the development of novel signal amplification technologies by Molecular Instruments, Inc. to enable automated, ultrasensitive, and multiplex imaging of RNA and protein expression in biological samples. The $1,099,625 award supports the engineering of two key capabilities: 1) a chromogenic signal amplification...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $147,656 to the University of North Carolina at Chapel Hill (UNC-CH) to support research on modular chimeric tRNA synthetases and their application in mRNA display technology. The goal is to develop a "plug-and-play" system for incorporating diverse non-canonical amino acids into macrocyclic peptide therapeutics, which can...
This $328,000 federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and application of an RNA editing platform called TRIBE-ID. The platform will be used to investigate dynamic RNA-protein interactions in cells, with the goal of advancing the understanding of RNA regulatory mechanisms and accelerating the development of RNA-targeted therapeutics....