This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the molecular and mechanistic bases of biofilm microbial communities. The $550,108 award to the University of California, Merced aims to investigate how transcriptional networks regulate gene expression during biofilm development, including in fungi, bacteria, and archaea that are commensals and/or pathogens of...
The National Science Foundation Division of Molecular and Cellular Biosciences awarded a $668,913 Project Grant to the University of Massachusetts Office of Grant & Contract Administration to support research titled "Collaborative Research: Model-Guided Design of Bacterial Interspecies Interactions and Trans-Organismic Communication in Living Intercellular Circuits." The award aims to advance understanding of interspecies biochemical cell-cell communication in natural microbial...
The National Institute of General Medical Sciences (NIGMS) awarded a $382,136 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Maryland, College Park. The 5-year grant, effective May 1, 2025 through March 31, 2030, supports research to define engineering principles for designing programmable bioengineered multicellular structures (probioms) in prokaryotic cells. The goal is to develop a framework for engineering probiotic-based...
This $1,003,736 federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to expand the understanding of post-transcriptional regulation of gene expression in bacteria. The research program has two main sub-projects: 1) Investigating epitranscriptomic regulation of gene expression across various bacterial species, and 2) Exploring the regulatory roles of novel...
This $462,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to decipher the genetic regulation of bacterial heterogeneity in response to antibiotic stress using single-cell transcriptomics. The research, conducted at St. Jude Children's Research Hospital, will employ bacterial single-cell RNA sequencing technology to map the genetic factors driving bacterial heterogeneity and elucidate...
This federal Project Grant award of $401,253 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to elucidate novel cyclic nucleotide signaling pathways and physiological effects in bacteria. The research program aims to investigate the molecular mechanisms that control 2',3'-cyclic nucleotide monophosphate (2',3'-cNMP) signaling in bacteria, including its effects on transcription,...
This $645,905 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to characterize chemotactic signaling and behavioral strategies in bacteria, with a focus on Vibrio cholerae and Pseudomonas aeruginosa. The research aims to extend experimental work previously conducted on Escherichia coli to pathogenic bacterial species, using techniques like single-cell fluorescence resonance energy...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $294,147 in funding to the University of Kansas Center for Research Inc. to advance modeling and simulation capabilities for macromolecular interactions in living cells. The project aims to apply efficient all-atom simulation protocols to characterize the intermolecular energy landscapes of different macromolecule types, simulate...
This $383,746 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to characterize the molecular mechanisms and evolution of cyclic diguanylic acid (c-di-GMP) signaling in the antibiotic-producing bacterial genus Streptomyces. The research will focus on three key areas: (1) understanding how c-di-GMP regulates the developmental life cycle in the model species Streptomyces...
The National Institute of General Medical Sciences (NIGMS) awarded a $463,157 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of California, Berkeley, with a subcontract to the University of Oregon. The objective is to measure and model how antimicrobial resistance (AMR) evolution depends on the self-organization of bacterial populations, ranging from microscale biofilms to gut-lumen distributed populations. The project will use...