This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $399,227 to the University of Oregon to investigate the mechanisms and consequences of host-pathogen evolution. The research aims to advance two key areas: 1) how rapid evolution of animal and bacterial cell surface receptors impacts colonization and immune evasion, and 2) how rapid evolution of host antimicrobial...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,106,322 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of Oregon (UO) on July 15, 2024. This grant supports a 5-year research program to investigate how the host nutrient environment drives bacteria to adopt recalcitrant physiological states, such as slow growth and biofilm formation, that enable chronic infections and antibiotic resistance. The research integrates techniques like...
This Project Grant award of $645,905 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to characterize the dynamics of chemotactic signal processing and collective migration in pathogenic bacteria. The funded research aims to extend experimental methods first explored in Escherichia coli to study chemotaxis in Vibrio cholerae and Pseudomonas aeruginosa. Key objectives include using single-cell...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
This Project Grant award of $779,235 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research into the mechanisms by which the bacterial second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) regulates motility and biofilm formation in Vibrio cholerae, the causative agent of cholera. The research aims to address gaps in understanding how c-di-GMP controls the motile-to-sessile lifestyle switch and...
This $1,273,110 federal Project Grant award, funded by the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program, supports a research project at the University of Michigan focused on understanding the molecular evolution of bacterial proteins that provide resistance to common antiseptic and antibacterial compounds. The key objectives of this 4-year project are to: 1) analyze the biophysical basis for how these bacterial resistance proteins export quaternary ammonium...
This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awarded to Baylor College of Medicine seeks to uncover the specific genes that confer antibiotic resistance in E. coli through a novel approach inspired by statistical physics. The $1,534,925 award spanning Aug 2024 to Jul 2027 will grow E. coli cultures and analyze the mutational ensemble using thermodynamic principles to predict the genes underlying antibiotic resistance. This technique aims to bridge...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $550,108 to the University of California, Merced to support research on the genetic regulation of microbial community formation, particularly in the context of biofilms. The research aims to understand the molecular and mechanistic bases of biofilm development, including how transcriptional networks regulate gene...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $422,931 to the University of Colorado-Denver to conduct research on characterizing the role of specialized microbial metabolites in shaping the structure and function of the human microbiome. The research aims to elucidate how these metabolite-driven microbial interactions influence community dynamics and susceptibility to...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 (Biomedical Research and Research Training), provides $967,980.00 to President And Fellows Of Harvard College, doing business as Harvard Medical School, to conduct research on evolutionary tradeoffs in antibiotic resistance. The project, entitled "EVOLUTIONARY TRADEOFFS IN ANTIBIOTIC RESISTANCE", aims to explore factors that impact the evolution of antibiotic...