This $462,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research by ST Jude Children's Research Hospital Inc. to decipher the genetic regulation of bacterial heterogeneity in response to antibiotic stress. Using single-cell transcriptomics, the research aims to identify key genetic factors driving antibiotic resistance and persistence in bacterial subpopulations, with the long-term goal of developing strategies to combat antibiotic treatment failure. The 5-year award period runs from January 1, 2025 through November 30, 2029 and will employ a synergistic approach of single-cell analysis and molecular genetics to characterize the functions of candidate regulatory genes and pathways mediating heterogeneous bacterial stress responses.
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