The National Institute of General Medical Sciences (NIGMS) awarded a $402,500 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The grant, effective January 1, 2025 through November 30, 2029, focuses on developing synthetic biology tools and strategies to streamline the engineering of bacterial theragnostics that can sense and respond to disease cues. The research aims...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,431,000 Project Grant to the Massachusetts Institute of Technology (MIT) to develop self-assembling nanomaterials that can protect microbes from processing, transportation, and storage stresses. The goal is to enable the production of important but challenging microbial therapeutics that are difficult to manufacture. The 3-year project, with an award date of September 18, 2023, aims to elucidate the mechanism by which...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to systematically identify and characterize novel gut microbial enzymes known as ene-reductases. The $390,000 award to the University of Maryland, College Park will fund a 5-year research project aimed at deepening the understanding of the critical role these enzymes play in shaping the chemical environment of the...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $550,108 to the University of California, Merced for a research project focused on understanding the genetic regulation of microbial community formation, particularly related to biofilms. The project aims to investigate the molecular and mechanistic bases of biofilm microbial communities, including how...
The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $541,967 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to expand understanding of adherent cell mechanics and mechanobiology. The grant will fund research to explore the force-sensitive remodeling of cell-cell adhesions and the role it plays in contact inhibition of proliferation, as well as investigate mechanisms of mechanosensing via LIM domain proteins within the...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,110,073 project grant (CFDA 93.859 Biomedical Research and Research Training) to the University of New Hampshire to develop DNA-based synthetic extracellular matrix (ECM) hydrogels. The goal is to create a versatile, controllable ECM mimic that can enhance regenerative medicine applications and provide deeper insights into cell-ECM interactions. The research program aims to independently tune the non-linear elasticity and...
The National Institute of General Medical Sciences (NIGMS) has awarded a 5-year, $724,640 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the Rochester Institute of Technology (RIT) to support research focused on engineering cell-substrate interactions on porous membranes. The goal is to advance the development of physiologically relevant microphysiological systems, or "tissue chips," that can be used for drug and toxicity testing, disease modeling, and...
This $463,157 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to measure and model how antimicrobial resistance (AMR) evolution depends on the self-organization of bacterial populations. The principal investigators at the University of California, Berkeley will leverage microfluidics, synthetic biology, and advanced imaging techniques to track the...
This $360,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate biological mechanisms for proton transfer. The goal is to design photoacid-binding proteins that can spectroscopically study proton dynamics in biological systems. The research will leverage computational protein design tools to position photoacid cofactors within designer protein scaffolds to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training Program, provides $396,510.00 to Brandeis University to conduct research on how archaeal microbes respond to mechanical stresses and environmental changes that mimic the human microbiome. The research aims to advance the mechanistic understanding of how microbiome complexity influences human physiology. The award supports a 5-year project (1/1/2025...