The National Institute of General Medical Sciences (NIGMS) awarded a $401,253 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Pennsylvania State University, doing business as Penn State, to elucidate novel cyclic nucleotide signaling pathways and physiological effects in bacteria. The research program will synthesize chemical tools and use in vitro and in cellulo techniques to interrogate the effects of 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) on bacterial transcription, translation, signaling pathways, and phenotypes in E. coli. The findings will then be extended to other bacterial species to understand the conservation and diversity of 2',3'-cNMP signaling, as well as the potential for targeting these pathways for new antibiotic development. The award period is from Feb 1, 2025 to Nov 30, 2029.
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