The National Institute of General Medical Sciences (NIGMS) awarded a $635,246 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Georgia Tech Research Corporation. The grant, effective September 1, 2024 through June 30, 2028, supports the development of innovative bioorthogonal chemistry methods to facilitate interactions between biomolecules and small molecules for site-selective transformations in biological systems. The key objectives include: 1)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop new synthetic strategies to functionalize pyridine and diazine heterocycles. The $259,966 award to Colorado State University will fund research to explore three approaches for azine functionalization: 1) installing heterocyclic phosphonium salts and exploiting their reactivity for coupling reactions, 2) utilizing...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Massachusetts Institute of Technology (MIT) for $351,010. The grant, with a period of performance from January 1, 2025 to November 30, 2029, focuses on the rational design, synthesis, and characterization of cationic carbone-boracycles as far-red and near-infrared photoactive agents for applications in bioimaging and cancer therapy....
The National Institute of General Medical Sciences (NIGMS) awarded a $401,233 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) federal grant program to Duke University, effective August 1, 2025 through May 31, 2030. The grant supports the development of new catalytic selective amination methods and aminofunctionalization cascades to expedite the synthesis and study of structurally diverse, nitrogen-containing molecules as probes and leads for advancing the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is funding a research program led by a professor at the University of Maryland, College Park. The program focuses on the design, synthesis, and characterization of new cucurbit[n]uril-type molecular container compounds, and investigating their potential applications in biomedical areas such as sequestration of biologically active substances like...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This federal Project Grant award of $146,816.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to develop general strategies for the biocatalytic synthesis of N-N and C-N heterobiaryl atropisomers, a class of medicinally relevant chiral compounds that are difficult to obtain through other methods. The research outlined will employ bioinformatic techniques to...
This Project Grant award, totaling $1,092,018.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research at Oklahoma State University (OSU) focused on two distinct but complementary objectives: Developing and advancing the fundamental understanding of nucleophilic cobalt photocatalysis, which aims to expand the available carbon radical precursors for synthetic organic...
This Project Grant award of $125,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to achieve two key objectives: Establish the first total syntheses of the bacterial metabolites azetidomonamide A, azetidopyridone, and diazetidomonapyridone, in order to enable the evaluation of their biological functions in quorum-sensing behavior and biofilm formation by Pseudomonas aeruginosa. This research could...
The National Institute of General Medical Sciences (NIGMS) awarded a $385,298 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York, doing business as Stony Brook University. The goal of this 5-year grant, which commenced on February 1, 2025, is to develop new biomimetic organic synthesis methods that leverage pyridoxal-5'-phosphate (PLP)-mimicking scaffolds and open-shell radical pathways,...