This federal Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports the development of a new bio-orthogonal mid-infrared photothermal imaging approach to quantitatively measure various molecular events in cancer cells at the subcellular level. The $407,113 award to Trustees of Boston University will be used to: 1) build a library of nitrile-based probes to sense important molecular events inside cancer cells; 2) develop...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $406,832 to develop novel boron-dipyrromethene (BODIPY)-based photo-uncaging groups. The research aims to create efficient red-to-near-infrared (red-to-NIR) light-responsive materials for applications such as precision drug delivery, neuron modulation,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $393,718 to Massachusetts Institute of Technology (MIT) to study the biogeography and combinatorial effects of microbial and plant-derived redox-active small molecules on microbial growth and community composition. The key objectives of this research are to: 1) Use newly developed screens to identify redox-active metabolites...
This federal Project Grant award of $1,590,000.00 was issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award was granted to the Massachusetts Institute of Technology (MIT) to support research aimed at developing predictive computational models for revealing the mechanisms of C-H activation catalysis by non-heme iron enzymes. The key objectives are to: 1) develop neural network potential models to...
This Project Grant award of $775,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to expand the chemical and functional space through boron-nitrogen heterocycles. The key products and services to be delivered under this 5-year award, which begins on September 10, 2024, include: Developing novel reactivity and selectivity in synthetic organic chemistry using boron-containing compounds that are not possible...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to advance the understanding of iron-sulfur enzymes and their reaction mechanisms. The key objectives include: Developing synthetic models of iron-sulfur enzyme intermediates to shed light on their structures and reactivity patterns through a combination of synthesis, spectroscopy, and mechanistic studies....
This Project Grant award, valued at $555,000.00 and awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program, supports research at the Massachusetts Institute of Technology (MIT) focused on developing advanced hybrid J-aggregate nanostructures. The primary objectives are to: Investigate how silica matrices influence the brightness, stability, and excitonic behavior of J-aggregate fluorophores, and explore solvent tunability through surface...
This $640,000 Project Grant was awarded by the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program to Professor Robert J. Gilliard at the Massachusetts Institute of Technology (MIT). The grant supports the design, synthesis, and characterization of boron-doped nanographenes, which are a class of graphene-based materials with potential applications in solar cells, LED screens, and other optoelectronic devices. The research focuses on two main thrusts:...
This $444,262 project grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of innovative reagents and methods for the synthesis of oligophosphate constructs. The key products and services to be delivered include: New reagents and methods for synthesizing oligophosphate chains up to pentaphosphorylation and beyond, including those with non-hydrolyzable P-C bonds. These...
This $381,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development and evaluation of tumor-targeting polymeric micelles carrying a near-infrared (NIR) imaging agent. The goal is to provide real-time optical image guidance during brain cancer surgery to improve tumor resection and surgical outcomes. The project aims to: 1) develop and characterize the tumor-targeting polymeric...