Project Grant R35GM154751

Award Date 9/1/24
Completion Date 6/30/29
Dollars Obligated $1.1M
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Stillwater, OK 74078, USA
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This Project Grant award, totaling $1,092,018.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research at Oklahoma State University (OSU) focused on two distinct but complementary objectives:

  1. Developing and advancing the fundamental understanding of nucleophilic cobalt photocatalysis, which aims to expand the available carbon radical precursors for synthetic organic chemistry applications. This work is expected to benefit medicinal chemistry by providing new synthetic methods and accessing novel chemical space.

  2. Exploring organic single-electron photoreductants as a general platform for visible-light-mediated radical generation directly from unactivated precursors such as alkyl halides and carbonyl compounds. This approach, enabled by halogen-bonding photocatalysis and 1,4-dihydropyridine anion photoreductants, is anticipated to yield new radical generation methods with improved functional group tolerance.

The award period runs from September 1, 2024 through June 30, 2029, with the goal of advancing fundamental scientific understanding and developing innovative synthetic tools to benefit the field of chemical synthesis.

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