This $986,486.00 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The primary goal of this 5-year project, awarded on May 6, 2025, is to discover new synthetic strategies and concepts to rapidly prepare biologically important and structurally complex molecules, particularly natural products from the Euphorbiaceae and Thymelaeaceae plant families. The research aims to...
The National Institute of General Medical Sciences (NIGMS) has awarded a $984,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to support the development of novel synthetic tools and strategies for accessing highly complex natural products. The project aims to leverage dearomative transformations of readily available aromatic compounds and desymmetrization of simple symmetrical precursors to access structurally...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $360,100 to The Regents of the University of California, Berkeley (UC Berkeley) to conduct research on supramolecular catalysis for pharmaceutical applications. The project aims to develop innovative synthetic methods leveraging supramolecular hosts to enable transformations relevant to the production of pharmaceuticals,...
This $450,313 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the molecular mechanisms and structural dynamics underlying multidomain enzymatic factories known as nonribosomal peptide synthetases (NRPSs). The research team at The Johns Hopkins University will leverage nuclear magnetic resonance (NMR) spectroscopy and computational approaches to determine...
This $401,595 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate labdane-related diterpenoid biosynthesis. The project, which runs from February 1, 2025 to January 31, 2030, will build on the awardee's previous work to elucidate the enzymes and metabolic pathways involved in producing these natural products. The research aims to engineer enzymes and pathways for...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), focuses on developing innovative drug delivery strategies to improve the pharmacokinetics and biodistribution of small molecule therapeutics. The $1,117,746 award, effective September 1, 2024 through June 30, 2029, supports two novel approaches: 1) designing albumin-binding targeted prodrugs, and 2) developing responsive polymer...
This $1,482,051 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research by the University of California, Davis to elucidate and manipulate the mechanisms by which terpenes and terpenoids, a class of natural products with diverse biological activities relevant to human health, are produced in nature. The research aims to rationally expand the chemical space of terpenes...
This Project Grant award, worth $584,420, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award supports research conducted by the Albert Einstein College of Medicine in the Bronx, NY to investigate the spatiotemporal mapping and engineering of proteins associated with intrinsic disorder, with a focus on the nuclear pore complex and protein splicing mechanisms using inteins. The research...
The National Institute of General Medical Sciences (NIGMS) awarded a $395,881 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Vanderbilt University to develop new protocols for altering the molecular topology of biologically active natural products and therapeutic compounds. The key objectives are to: Develop photochemical deconstructive epimerization methods to enable rapid modification of existing natural product and drug libraries by inducing C-C bond cleavage,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,114,113 in funding to the University of North Carolina at Chapel Hill (UNC-CH) to develop reactions that enable molecular rigidification. The goal is to create new methods for accessing rigid small and medium-sized strained rings, as well as techniques to stabilize highly reactive alkylidene units using palladium catalysis. The...