Project Grant K99GM157554

Award Date 9/12/24
Completion Date 8/31/26
Dollars Obligated $125K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Pasadena, CA 91125, USA
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This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $125,000.00 to the California Institute of Technology (Caltech) to support research with two key objectives:

  1. Establish the first total syntheses of azetidomonamide A, azetidopyridone, and diazetidomonapyridone, novel bacterial metabolites that affect quorum-sensing behavior and biofilm formation in Pseudomonas aeruginosa. This research aims to expand understanding of these metabolites' biological functions and their potential for developing anti-virulence treatments.

  2. Develop new organometallic methods to access modular, bifunctional strained-ring and heterocycle chemical building blocks with pharmacological relevance. This research will broaden knowledge of chemical reactivity and provide strategies for synthesizing molecular scaffolds applicable across multiple industries.

The award period runs from Sep 12, 2024 to Aug 31, 2026, and the research will be conducted at Caltech.

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