Project Grant R34NS144925
- The National Institutes of Health (NIH) awarded a $1,385,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute, a non-profit research organization, to develop novel techniques for measuring the input-output operations of individual neurons in the mouse cortex. The project aims to overcome challenges in understanding how neurons in the mammalian brain transform their synaptic inputs into outputs, which is critical for designing effective brain-machine...
- The National Institute of Neurological Disorders and Stroke awarded $462,148 to The Trustees of Columbia University in the City of New York on July 8, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). Columbia will develop and benchmark functional graphene nanoribbon (F-GNR) neural probes as ion-selective, multimodal recording tools for neuroscience. The project addresses the lack of existing tools with sufficient molecular...
- The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University $557,161 on July 10, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to develop a novel bioluminescence resonance energy transfer (BRET) system for optimizing and imaging in vivo recording of neural activity in freely behaving animals. The project runs through June 30, 2029, with performance in Nashville, Tennessee. The award supports...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Utah $616,000 on August 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (Assistance Listing 93.372) to develop a high-throughput computational pipeline for rapid design of photocaged neuropeptides. The project addresses the NIH BRAIN Initiative goal to enable precise modulation of neural circuit components by creating a generalizable, open-source...
- The Johns Hopkins University was awarded a $2,008,605 Project Grant under the National Institute of Neurological Disorders and Stroke's 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant funding will support the development of an "Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation." This adaptive multiphoton microscope system will leverage hybrid volumetric scanning,...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Yale University $272,970 under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative on September 30, 2025. The award funds research on neural circuits regulating arousal and behavioral responses to visual threats. The project employs a virtual visual cliff task in mice to study the relationship between neuromodulators (norepinephrine and acetylcholine), attention, arousal, sensory...
- The National Institute of Neurological Disorders and Stroke awarded Trustees of Dartmouth College $1,010,880 on May 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to translate a novel carbon-coated neurochemical sensor technology toward integrated neurotransmitter sensing in humans. Dartmouth will develop designs to integrate fast-scan cyclic voltammetry (FSCV)-based dopamine and neuromodulator sensing capabilities into...
- The National Institute of Neurological Disorders and Stroke awarded Trustees of Boston University $595,774 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop far-red microscopy techniques and genetically engineered voltage indicators for deep-tissue imaging of large neuronal populations in the mouse brain. The project develops two complementary microscope systems optimized for high-speed voltage imaging at...
- The National Institute of Neurological Disorders and Stroke awarded Cornell University a $686,023 Cooperative Agreement on July 8, 2026, to develop non-invasive optical imaging technology for visualizing brain structure and function at the cellular level. Cornell will advance three-photon microscopy (3PM) imaging techniques and develop new lasers to increase three-photon fluorescence signal by approximately 10,000 times. This advancement will enable visualization of mouse brain activity with...
The National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health) awarded $361,125 to the University of California, Berkeley on September 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) as a project grant. The award funds a targeted planning project to establish a functional connectomics paradigm combining ultra-fast two-photon voltage imaging (2P-FACED) with two-photon optogenetic stimulation. The system will measure, monitor, and track synaptic weights across tens of thousands of candidate synaptic connections in awake rodent brains over days to weeks to months. The approach reads both subthreshold synaptic potentials and suprathreshold spikes, enabling direct measurement of monosynaptic connectivity and its functional impact on spiking in the same neurons in vivo. The platform is designed as a general-purpose system for measuring and dynamically tracking functional connectomes throughout the brain, addressing limitations in existing connectomics approaches that operate only on post-mortem tissue, have low throughput, or sparsely sample local regions. The period of performance runs from September 1, 2026, through August 31, 2028. Work is performed in California.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $361.1k | 8/31/26 |