Project Grant R34AR087629
- The National Institutes of Health Office of the Director awarded Michigan State University (operating as Henry Ford Health+Michigan State University Health Sciences) $1,403,056 under the Trans-NIH Research Support program (CFDA 93.310) on April 23, 2026, to identify mechanisms of lung toxicity from skin exposure to vesicants. The recipient will conduct research establishing the role of mast cells and delineating mechanisms of acute and long-term lung toxicity from dermal exposure to mustard...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Tennessee Health Science Center $466,103 on May 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to characterize nitrogen mustard-induced ocular surface injury (NMOSI) models in mice and test the hypothesis that vesicating ocular injury pathology involves bioactive sphingolipid pathways for acute and chronic inflammation and corneal, conjunctival, and...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded The Johns Hopkins University $116,625 on July 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to interrogate glutamate carboxypeptidase II (GCPII)-mediated glutamate signaling in the gastrointestinal tract and its role in intestinal homeostasis. The research addresses an unmet clinical need for mechanistically novel therapeutics to treat inflammatory bowel disease, as up...
- The National Institutes of Health Office of the Director awarded University of Alabama at Birmingham $408,373 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, for a project grant (R21AR087354) investigating the cGAS-STING pathway as a mechanism-based medical countermeasure for vesicant skin injury caused by arsenical chemical agents. The award funds research using murine models to test whether arsenicals trigger skin inflammation and blistering through Type-I...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded Old Dominion University $458,144 on June 23, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate 2-arachidonoylglycerol signaling as a therapeutic target for nitrogen mustard-induced lung injury. The research aims to assess the efficacy of monoacylglycerol lipase (MAGL) inhibition in protecting against nitrogen mustard-induced acute lung injury, inflammatory...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $197,600 on September 21, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify metabolic targets that can reinvigorate exhausted CD8+ T cells. The award is classified as a Project Grant. The research applies untargeted liquid chromatography-mass spectrometry-based metabolomics to characterize the distinct metabolic profile of exhausted T cells compared to...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded The Johns Hopkins University a $2.71 million Project Grant (effective August 6, 2025 through July 31, 2030) under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the neurobiological mechanisms underlying paclitaxel-induced peripheral neuropathy (PIPN). The award supports research utilizing novel whole dorsal root ganglia (DRG) in vivo imaging technology to monitor sensory...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded The Johns Hopkins University $420,936 for a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on April 1, 2026. The award funds research investigating mechanisms of protein self-assembly coupled to membrane mechanics in clathrin-mediated endocytosis. The research addresses how cargo controls the nucleation and growth of...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $133,515 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a multi-omic mass spectrometry imaging platform for visualizing inflammatory disease biomarkers in tissue sections. The funded work addresses technical limitations in current matrix-assisted laser desorption/ionization mass spectrometry imaging approaches by developing optimized protocols and...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $125,000 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify resistance mechanisms in parasitic nematodes to anthelmintic drugs levamisole and pyrantel. The research investigates how nicotinic acetylcholine receptor (nAChR) agonists lose effectiveness against parasitic nematode infections in humans, livestock, and animals worldwide. The award funds...
The National Institutes of Health Office of the Director awarded The Johns Hopkins University $247,337 on August 18, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate glutamine metabolism and vesicant pathogenesis in response to NOFO-PA-25-093. The project will characterize the metabolic consequences of nitrogen mustard and phenylarsine oxide exposure in keratinocytes using in vivo mouse models of skin exposure, performing untargeted imaging mass spectrometry for spatial metabolomics and single-cell RNA sequencing to elucidate shared transcriptional changes in metabolic pathways. The work will assess how vesicants disrupt glutamine metabolism, impairing de novo nucleotide synthesis and glutathione production pathways and thereby increasing oxidative stress and cytotoxicity. A second aim will elucidate the protective roles of glutamine metabolism in DNA repair and glutathione-mediated defense mechanisms upon vesicant exposure, using pharmacological inhibitors of glutamine metabolism and evaluating the therapeutic potential of glutamine supplementation in murine models. Performance of work occurs in Baltimore, Maryland. The award carries a period of performance through July 31, 2029. This is a project grant, a form of assistance funding under the Trans-NIH Research Support program, which covers multiple offices in the NIH Office of the Director and evaluates applications for scientific and technical merit by peer review and program relevance by national advisory council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $247.3k | 8/18/26 |