Project Grant K99AI199993
- The National Institute of Allergy and Infectious Diseases awarded Iowa State University $453,063 on February 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify and characterize drug efflux transporter systems in parasitic nematodes as targets for new anthelmintic therapies. The research identifies transporter mRNAs expressed in nematodes in the presence and absence of anthelmintic drugs, characterizes drug binding to nematode transporters using...
- The National Institute of Allergy and Infectious Diseases awarded George Washington University $444,125 on February 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify genetic determinants of host immunity-mediated resistance to helminth infection. The project will use recombinant collaborative cross mice with high genetic variability to uncover novel genetic determinants of host immune responses during Ascaris infection through phenotypic screening...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $149,190 on January 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support Project Grant F31AI191794, a doctoral fellowship examining mechanisms of antibiotic persistence in a mouse model of systemic infection. The research develops and uses a mouse model of systemic bacterial infection to study how phenotypically distinct bacterial subpopulations survive...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $195,640 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research integrating genomic and clinical approaches to define and prevent cefiderocol resistance in carbapenem-resistant organisms. The research addresses gaps in understanding cefiderocol resistance mechanisms and clinical use in carbapenem-resistant organisms, which cause severe...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $225,628 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify genetic mechanisms of polyene resistance in Candida glabrata using saturating transposon mutagenesis coupled with next-generation DNA sequencing (TN-SEQ). The project will implement TN-SEQ to mutate and barcode every gene in C. glabrata and profile resistance to three approved...
- The National Institute of Allergy and Infectious Diseases awarded Emory University $161,244 on April 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct experimental evolution assays elucidating evolutionary trajectories to antibiotic resistance in Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, and how the immune system modifies these trajectories. The research uses in vivo adaptive laboratory evolution experiments in Galleria...
- The National Institute of Allergy and Infectious Diseases awarded Whitehead Institute for Biomedical Research $899,850 on February 20, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how apicomplexan parasites recognize and invade host cells. The funded research examines the molecular mechanisms by which parasites such as Toxoplasma and Plasmodium trigger rhoptry discharge—the secretion of proteins from specialized organelles upon contact with host...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $765,422 on April 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on mechanisms of antigen diversification in Trypanosoma brucei. The research investigates how T. brucei, an extracellular protozoan parasite endemic to sub-Saharan Africa, evades host antibody clearance through periodic switching of its variant surface glycoprotein (VSG) coat. The...
- The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $233,125 on May 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how the bacterial pathogen Legionella manipulates host cell peroxisomes to evade immune defenses. The research focuses on elucidating the molecular mechanisms by which Legionella alters peroxisome biology and recruits peroxisomes to its replication vacuole, with emphasis on identifying...
- The National Institute of Allergy and Infectious Diseases awarded the University of Maryland, Baltimore $440,211 on April 16, 2026, to support research on epigenetic regulation of neo-sex chromosomes in filarial parasites under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research examines sex chromosome evolution and gene regulation in filarial nematodes, obligate vertebrate parasites that cause significant morbidity and mortality in tropical regions. Filarial...
The National Institute of Allergy and Infectious Diseases awarded The Johns Hopkins University $125,000 on August 4, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify resistance mechanisms in parasitic nematodes to anthelmintic drugs levamisole and pyrantel. The research investigates how nicotinic acetylcholine receptor (nAChR) agonists lose effectiveness against parasitic nematode infections in humans, livestock, and animals worldwide. The award funds examination of both target-site resistance and non-target-site resistance mechanisms, using Caenorhabditis elegans as a model organism to determine how nematodes develop resistance to these critical anthelmintic drugs. The project will analyze how nAChR agonists affect nematode development, gene transcription, and metabolite abundances, and will narrow quantitative trait loci from genome-wide association studies linked to variation in levamisole and pyrantel resistance. Performance period runs through July 31, 2028, with work performed in Baltimore, Maryland. The award is a project grant, the assistance type supporting biomedical research and research training in infectious diseases and related areas through the National Institutes of Health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 8/4/26 |